Protein Alignment hppy and Map4k5

DIOPT Version :10

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_958927.2
• Gene: Map4k5 / 399510
• MGIID: 1925503
• Length: 847
• Species: Mus musculus
• Alignment Length: 1218
• Identity: 481/1218 - (39%)
• Similarity: 619/1218 - (50%)
• Gaps: 391/1218 - (32%)

  Fly    14 SSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDC 78
            ::||.|||||.:|||:|::|||||||||||:.:.:.||||:|:|||||.||..:|||||.|:::|
Mouse     8 AADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKEC 72

  Fly    79 RHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            :|.||:||:||||.|:|||||||:||||||||||.|||||:|:||||:|||||:||.|||:.|||
Mouse    73 KHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLHTKGKM 137

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208
            ||||||||||||::||||||||||:|:|||||.||||||||||||||||||||:.||||||||||
Mouse   138 HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIW 202

  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273
            |.|||||||.|||||||||||||||||||||.|:||.|.:|.|||.|||||:|.|||||||||||
Mouse   203 AVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPT 267

  Fly   274 AERLLQHPFV-QCEMSLRVAKELLQKYQSPN---PQFYYYLDGDEESVAGVPQRIASKMTSRTNG 334
            |||||.|.|| |..:|..:|.|||.|..:|:   |    |.:|||:.:.  |..|.
Mouse   268 AERLLTHTFVGQPGLSRALAVELLDKVSNPDNHAP----YSEGDEDDLE--PHAII--------- 317

  Fly   335 VPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCS 399
                .||::   :||     |:|..|...|:::.     ::|:....|....:.:|.:|..
Mouse   318 ----RHTIR---STN-----RNSRAERTASEINF-----DKLQFEPPLRKETEARDEMGLS---- 361

  Fly   400 SHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLP 464
                                                              ..||.:
Mouse   362 --------------------------------------------------SEPNFI--------- 367

  Fly   465 QQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGM 529
                           .|.:|.....::|..|:..   :....|...|.::.|
Mouse   368 ---------------LHWNPFVDGANTGRSTSKR---AIPPPLPPKPRVNTY------------- 401

  Fly   530 GFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSN 594
                              .:|.|  .|...::.....|            ...|.|...||..|:
Mouse   402 ------------------PEDSL--PDEEKSSTIKRCP------------DLEARAPQVLRRQSS 434

  Fly   595 YRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNG 659
            ......|:.|                       |||                          |||
Mouse   435 PSCVPVAETS-----------------------SSI--------------------------GNG 450

  Fly   660 GGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSS 724
            .|.|.:.|
Mouse   451 DGISKLIS--------------------------------------------------------- 458

  Fly   725 SNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPR 789
                            |...||:.|
Mouse   459 ----------------ENTEGSAQA---------------------------------------- 467

  Fly   790 TRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKI 854
                                        |..|::..||..  |:|..|||||||||.|||||||:
Mouse   468 ----------------------------PQLPRKKDKRDF--PKPTINGLPPTPKVLMGACFSKV 502

  Fly   855 FNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMS 919
            |:||||:::|..|||||:|:||:::.|.|:|||.||:||||:|.::|||||:.||||||.:.|||
Mouse   503 FDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMS 567

  Fly   920 LS-GKSCQLYRHDLVALH---SKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNP 980
            || ||:.|||.|:|:||.   .|..:...:..::.|:|::|||||||||:||||.|.:||:.|||
Mouse   568 LSEGKTFQLYSHNLIALFEQAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNP 632

  Fly   981 YNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTP--VFEMIITPE 1043
            |.|:||||||..|||.|:|||:|:.||||:|..::|..|              |  ||||::.||
Mouse   633 YTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPS--------------PLNVFEMLVIPE 683

  Fly  1044 LEYPIVCTGVRKAMNG--CLKLELINMNSA-SWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKD 1105
            .|||:||..:.|..:.  .::.|.||:||| |||    .|..|.:..      |..:.|.|:|:|
Mouse   684 QEYPMVCVAISKGSDSSQVVQFETINLNSASSWF----TEIGAGSQQ------LDSIHVTQLERD 738

  Fly  1106 AILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQ 1170
            .:|||....:::|.|||..|..||:.|:|:|||.::|:|||.||||||.||||||||.::.||||
Mouse   739 TVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQ 803

  Fly  1171 EIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218
            ||.|.:|.:||||||:||.|||:.....:..|    :||||||||.||
Mouse   804 EISDETRVFRLLGSDRVVVLESRPTENPAAHS----NLYILAGHENSY 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	202/257 (79%)
		CNH	864..1193	CDD:470577	171/337 (51%)
Map4k5	NP_958927.2	STKc_MAP4K5	10..277	CDD:270813	209/266 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..487		36/348 (10%)
		CNH	512..827	CDD:214481	172/338 (51%)