DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Myo3b

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001380706.1	Gene:	Myo3b / 366069	RGDID:	1560313	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	127/321 - (39%)
Similarity:	194/321 - (60%)	Gaps:	35/321 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQE 71
            |:|:.||..: |..:|.|.:|:.:.||.||||.|||....:...|||:|::     |.:..:.:|
  Rat    25 HYNSMMLRLE-SLPDPMDTWEIRETIGKGTYGKVYKVANRRDGSLAAVKIL-----DSVNDVDEE 83

  Fly    72 I-----IMMRDCRHPNIIAYYGSYLRRDK-----LWICMEFCGGGSLQDIYQVTG------PLTE 120
            :     |:.....|||::.:||.:.:.|:     ||:.:|.|.|||:.::  |.|      .|.|
  Rat    84 VEAEYNILQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTEL--VKGLLRCGKRLDE 146

  Fly   121 VQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTP 185
            ..|:|:...:|.||::||....:|||:||.|||||..|.|||.|||||||:|:|..:|.:.:|||
  Rat   147 ALISYILYGSLLGLQHLHHHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTP 211

  Fly   186 YWMAPEVAAVERK--GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNN 248
            :||||||.|.|::  ..|:..||:|:.|||||||.:..||:|::||::.||.:.::  .||||.:
  Rat   212 FWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRN--PPPTLLH 274

  Fly   249 KDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQ------CEMSLRVAKELL-QKYQSP 302
            .|.|...|::||...|.|:.:|||:...||.|||::      ..:..::||.|. ||:|:|
  Rat   275 PDNWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLFLQKQLAKVLWDQKHQNP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	112/275 (41%)
		S_TKc	26..283	CDD:214567	112/274 (41%)
		CNH	869..1184	CDD:279162
Myo3b	NP_001380706.1	MYSc_Myo3	373..1062	CDD:276830
		IQ	1102..1124	CDD:197470
		PKc_like	20..310	CDD:419665	120/294 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910