DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and ninaC

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	151/525 - (28%)
Similarity:	240/525 - (45%)	Gaps:	118/525 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD-CRHPNII 84
            :|.|::|:.::|..|....|::||.:.::.:.|:|:...:....:. |::|...:|| |.|||:.
  Fly    11 DPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVS-IEEEYRTLRDYCDHPNLP 74

  Fly    85 AYYGSY-LRR----DKLWICMEFCGGGSLQD----IYQVTGPLTEVQIAYMCRETLKGLEYLHSM 140
            .:||.| |.:    |::|..||:|.||:..|    :.::...:.|..|||:.|||.:....|:..
  Fly    75 EFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRN 139

  Fly   141 GKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPE-VAAVE-RKGGYNQ 203
            ..:||||:|.|||||:.|.|||.|||:|.|:.:|:.||.:.||:|.||||| |:|:| |:.....
  Fly   140 HVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDITV 204

  Fly   204 LCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNP 268
            ..|:||.|||.||||:.:||..|:||.||:|.:.::  .||||.....||...::||..:|.||.
  Fly   205 RADVWALGITTIELADGKPPFADMHPTRAMFQIIRN--PPPTLMRPTNWSQQINDFISESLEKNA 267

  Fly   269 KKRPTAERLLQHPFV------QCEMSLRVAKELLQ-----KYQSPNPQFY----YYLDGDEESVA 318
            :.||....:::|||:      :.||...:| |:|:     |.....|:.:    |....||:...
  Fly   268 ENRPMMVEMVEHPFLTELIENEDEMRSDIA-EMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEK 331

  Fly   319 GVPQRIAS-KMTSRTNGVPAQNHTLKTG----------MTTNSTWNE--------------RSSS 358
            ..|:.:|: :.....|.:.:..|.:..|          ::.||  ||              ..|.
  Fly   332 MYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNS--NEIKQEFPQEFHAKYRFKSR 394

  Fly   359 PETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAA------------GGGGG 411
            .|..|...|:.....:::       |::  |:|.....|..|::|.:.            |.|..
  Fly   395 SENQPHIFSVADIAYQDM-------LHH--KEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNR 450

  Fly   412 GGVG------------VGAGGAAAN-------------GSSSSSGGA--------------TVGT 437
            |..|            |.||....|             |.:....||              |.||
  Fly   451 GATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGT 515

  Fly   438 THHQH 442
            .|:.|
  Fly   516 QHNFH 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	103/269 (38%)
		S_TKc	26..283	CDD:214567	103/268 (38%)
		CNH	869..1184	CDD:279162
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	105/273 (38%)
		S_TKc	16..282	CDD:214567	103/268 (38%)
		MYSc	327..1034	CDD:214580	36/205 (18%)
		MYSc_Myo21	346..1022	CDD:276848	33/186 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910