DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Tao

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	195/641 - (30%)
Similarity:	278/641 - (43%)	Gaps:	149/641 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKL---EPSDDIQIIQQEIIMMRDCR 79
            ::.:|:..:|.:::||.|::|.||.|:...:.|:.|||.:..   :..:..|.|.:||..:|...
  Fly    19 NKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLN 83

  Fly    80 HPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQV-TGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            |||.|.|.|.|||....|:.||:| .||..||.:| ..||.|.:||.:|...|.||.||||:|::
  Fly    84 HPNTIEYKGCYLRESTAWLVMEYC-VGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRI 147

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208
            |||||..|||||:.|.||||||| ||.|....|   ||:||||||||||.....:|.|:...|:|
  Fly   148 HRDIKAGNILLTDNGVVKLADFG-SAAIKCPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDVW 208

  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273
            :.|||.|||||.:||.|:::.|.||:.::::  :.|||...| ||..|.:|::..|.|.|.:||:
  Fly   209 SLGITCIELAERKPPYFNMNAMSALYHIAQN--ESPTLPKND-WSDAFCSFVELCLKKMPAERPS 270

  Fly   274 AERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQ 338
            :.:||.|.:|....|..|..||:.:.:|                   ..|....:..|.......
  Fly   271 SAKLLTHAYVTRPRSDTVLLELIARTKS-------------------AVRELDNLNYRKMKKILM 316

  Fly   339 NHTLKTGMTTNSTWNER-------SSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAEC 396
            ..|.:|......|.:::       ||...::.|:.|:
  Fly   317 VDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSI---------------------------- 353

  Fly   397 SCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQ------------HH 449
                |:             ||...|::..|||:|..|.....||....|||            ||
  Fly   354 ----HS-------------VGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHH 401

  Fly   450 HHPNHLHQHQSHQLPQQQQQQ----SHQAAQQEHHHHHPMTSSISSGLVTANANNI--SSSASLA 508
            |||   ||......|..||.|    ...:.....|.:.|...:|...:    .||:  ::|||:.
  Fly   402 HHP---HQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSM----NNNVTPTNSASVV 459

  Fly   509 SMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGA 573
            ..|..:..|.....|:.|:                                 :|...|.|.|:|.
  Fly   460 PAPAPAPVLPPPISVLPHL---------------------------------SAMGHVGGGGTGT 491

  Fly   574 GNGSGSGCSAS----AAHYLRYSSNYRSAAAAQASQAAHPHVNSN---SNSNNGHG 622
            | |||.|..||    |.........|.:..||||:..|....:|.   ||:.|.||
  Fly   492 G-GSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHG 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	117/261 (45%)
		S_TKc	26..283	CDD:214567	117/260 (45%)
		CNH	869..1184	CDD:279162
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	118/264 (45%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	117/260 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840