Protein Alignment hppy and Mink1

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_006246778.1
• Gene: Mink1 / 303259
• RGDID: 1359135
• Length: 1384
• Species: Rattus norvegicus
• Alignment Length: 1449
• Identity: 345/1449 - (23%)
• Similarity: 524/1449 - (36%)
• Gaps: 503/1449 - (34%)

  Fly    16 DISR-RNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD-C 78
            |:|. |:|...:||::.:|:||||.|||.:.:::.:||||||:.: ..|:.:.|:|||.|::. .
  Rat    14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV-TEDEEEEIKQEINMLKKYS 77

  Fly    79 RHPNIIAYYGSYLRR------DKLWICMEFCGGGSLQDIYQVT--GPLTEVQIAYMCRETLKGLE 135
            .|.||..|||:::::      |:||:.|||||.||:.|:.:.|  ..|.|..|||:|||.|:||.
  Rat    78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142

  Fly   136 YLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERK-- 198
            :||:...:||||||.|:||||..:|||.|||||||:..|:.:|.:||||||||||||.|.:..
  Rat   143 HLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207

  Fly   199 GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTA 263
            ..|:...|||:.||||||:||..||:.|:||||||||:.::  .||.|.:| |||..|.:||.|.
  Rat   208 ATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK-KWSKKFTDFIDTC 269

  Fly   264 LTKNPKKRPTAERLLQHPFV-------QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEE------ 315
            |.|....||..|:||:.||:       |..:.|:...:..:|.:....:..|...|.||
  Rat   270 LIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHG 334

  Fly   316 ------SVAGVP---------QRIASKMTSRTNGVPAQN-------------------------- 339
                  |:..||         .|:..:..|.:..:..|.
  Rat   335 EEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIE 399

  Fly   340 ----------------------------------HTLKTGMTTNSTWNERSSSPETLPSDMSLLQ 370
                                              ..|:..........|:......|..:...|:
  Rat   400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLE 464

  Fly   371 YIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATV 435
            .:.::|.....|.|....|.
  Rat   465 ILQQQLLQEQALLLEYKRKQ--------------------------------------------- 484

  Fly   436 GTTHHQHQ------QHHQHHHHPNHL--HQHQSHQLPQQQQQQSHQAAQQEH-----------HH 481
              ...|.|      |..|.|.:...|  .|.|..||.:|||||..|..||:.           :|
  Rat   485 --LEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQQLQKQQQQQQQQQQQQQQQQILPGDRKPLYH 547

  Fly   482 H----HPMTSSISSGLVTANAN-NISSSASLA------------------SMPG-LSAYLGMRSH 522
            :    :|......:..|...|. |...::.||                  |.|| ||....|:..
  Rat   548 YGRGINPADKPAWAREVEERARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRP 612

  Fly   523 VVGHMGMGFGMGLGMSNL--------RTTSI-DADDDELVAADVAMNNAAAAVP---GNGSGAG- 574
            |....|....:......|        |:.|: |.....|.|...:.:...||||   ...|..|
  Rat   613 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGA 677

  Fly   575 --------NGSGSGCSASAAHYLRYSS-----------------NYRSAAAAQASQA--AHPHVN 612
                    ...|.|.|.:...::|..:                 |...|..::.:||  |.|..|
  Rat   678 VIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSN 742

  Fly   613 S----------------------------NSNSN------------------NGHGHAPITSSIS 631
            |                            |::||                  ..|||.|...|:.
  Rat   743 SAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLE 807

  Fly   632 SSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISSSGGASSGTNG------------------- 677
            .:.      ||:                |.|:.:.||...|.|...
  Rat   808 RNR------NRV----------------GASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAI 850

  Fly   678 -----LLDKHELDALPQAATKSAGDGFSHSNSPTANS--------GAGATGSRDNDG-------- 721
                 ||.:..||..|:...|:.  .:|.|:....:|        |..:.||||..|
  Rat   851 GEDFVLLKERTLDEAPKPPKKAM--DYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTD 913

  Fly   722 -----------------PSSSNSSHLYQN--------LLRSSSGET-------PAGSSSAGNNCD 754
                             ||....:.:.|.        ||..|:|.|       |:.|.:
  Rat   914 SVSTMVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPT------ 972

  Fly   755 YRHENNQNGLEDSPRRHSSMD-QLIGLLENMGKSPRTRSL-----SDGGTQDD------------ 801
               ||:|.  :..|.:....| |..||::..|||..|..:     ..||:.|.
  Rat   973 ---ENSQG--QSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGG 1032

  Fly   802 --DEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHC 864
              |:.:.:.:...:.|..|     ::.|.|:          .||::..   :.|.||.   .:.|
  Rat  1033 RLDQLQFDVRKGSVVNVNP-----TNTRAHS----------ETPEIRK---YKKRFNS---EILC 1076

  Fly   865 TASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIK--DVLMSLSGKSCQL 927
            .|.|      ..:||:|.|.|:..|:.:. .......:..||...:.|::  ::|:::|||..:|
  Rat  1077 AALW------GVNLLVGTENGLMLLDRSG-QGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKL 1134

  Fly   928 YRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATP 992
            ..:.|..|.:|     .||.:  ||  |.:|...|| |.|.:.|....|.:  |...|:|..|..
  Rat  1135 RVYYLSWLRNK-----ILHND--PE--VEKKQGWTT-VGDMEGCGHYRVVK--YERIKFLVIALK 1187

  Fly   993 SGIFLMQWY-DPLNKFMLLKQ-CEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRK 1055
            :.:.:..|. .|.:|||..|. .:.|               |.|:...:...|.:
  Rat  1188 NSVEVYAWAPKPYHKFMAFKSFADLP---------------HRPLLVDLTVEEGQ---------- 1227

  Fly  1056 AMNGCLKLELINMNSASWFHSEDLE----YDA-------------MATMVPRRDLLKVVRVHQVE 1103
                  :|::|..:||. ||:.|::    ||.             ....:|..|.::::..:  |
  Rat  1228 ------RLKVIYGSSAG-FHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCY--E 1283

  Fly  1104 KDAILV-CYGNLIQVVTLQ 1121
            .:.:.| .||.:|:.|.||
  Rat  1284 DEGVYVNTYGRIIKDVVLQ 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	131/268 (49%)
		S_TKc	26..283	CDD:214567	131/267 (49%)
		CNH	869..1184	CDD:279162	62/275 (23%)
Mink1	XP_006246778.1	STKc_MAP4K4_6_N	8..289	CDD:270806	135/278 (49%)
		S_TKc	25..289	CDD:214567	131/267 (49%)
		CNH	1066..1364	CDD:214481	68/293 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910