Protein Alignment hppy and Map4k1

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001099713.1
• Gene: Map4k1 / 292763
• RGDID: 1305463
• Length: 827
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 359/1195 - (30%)
• Similarity: 519/1195 - (43%)
• Gaps: 398/1195 - (33%)

  Fly    12 MLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMR 76
            ::..||..::|::.|:|:|::|.||||:|:||:...|.:|.|:|::|:||.||:..:|:||:|::
  Rat     3 LVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVSTLQKEILMLK 67

  Fly    77 DCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMG 141
            .|||.||:||:||||...||||||||||.|||||||||||.|:|:||:|:|||.|:||.||||..
  Rat    68 SCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQK 132

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |:||||||||||:.:.|:|||||||:||||.||:.:|.||||||||||||||||..|||||:|||
  Rat   133 KIHRDIKGANILINDSGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCD 197

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            ||:.|||||||||||||:||:||:|.||||:|||::||.|..|.|||.:||||:|..||||.|||
  Rat   198 IWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSSSFHNFVKVTLTKNSKKR 262

  Fly   272 PTAERLLQHPFV-QCEMSLRVAKELLQKYQSPNPQFYYYLDGDE-ESVAGVPQRIASKMTSRTNG 334
            |:|.::|.|..| |..::..:..:||.|.::|.......::.:| |....:|:||.|...:.:.|
  Rat   263 PSATKMLSHQLVSQPGLNRGLILDLLDKMKNPGKGLPVEIEDEEPEPPPAIPRRIRSTYRASSLG 327

  Fly   335 VPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCS 399
            :|                                                        .|:| |
  Rat   328 IP--------------------------------------------------------DADC-C- 334

  Fly   400 SHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLP 464
                                                                    .:|...|.|
  Rat   335 --------------------------------------------------------RRHMEFQRP 343

  Fly   465 QQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGM 529
            :..:.:|.                       |:...:..||...|
  Rat   344 RCVECRSQ-----------------------ADTVLLQPSADFRS-------------------- 365

  Fly   530 GFGMGLGMSNLRTTSIDADDD-ELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSS 593
                    ::.|:...|:||| :.|.......|....:|
  Rat   366 --------TSPRSQLSDSDDDYDDVDIPAPSENLPPPLP-------------------------- 396

  Fly   594 NYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGN 658
                         ..|.:.|.|:.
  Rat   397 -------------PKPKIRSPSDD----------------------------------------- 407

  Fly   659 GGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPS 723
              ||..:...|..|.|.
  Rat   408 --GSGGVRDDGQLSPGV------------------------------------------------ 422

  Fly   724 SSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSP 788
                      |:|.:||..|.                                    :...|..|
  Rat   423 ----------LVRCASGPPPR------------------------------------IPRPGPPP 441

  Fly   789 RTRSLSDGGTQDDDEAEKEAQPDLLN------NTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHM 847
            .|||         ......:.|.|.|      ..||:.|.|..|.|    :.:.|    ..:...
  Rat   442 ATRS---------PHLTARSDPSLWNPAAPEPGQPPLLPPRKEKMR----KKMEN----EKRREE 489

  Fly   848 GACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYV 912
            .....|:||||||::|.||:|.||.|:|||||:||||||:.||.|: .:|.::.:||.||||||.
  Rat   490 YTLLVKLFNGCPLQIHSTAAWTHPSTKDQHLLLGAEEGIFILNRND-QEATLEMIFPGRTTWLYC 553

  Fly   913 IKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKI-PERLVPRKFALTTKVPDTKCCTQCCV 976
            |.::|||||||:..||.|.::.|..::.||....:..| |.|.:.||..:::|:.|||.|..|||
  Rat   554 INNLLMSLSGKTPHLYSHSILGLLERKEVRTGSPIAHISPHRFLARKNMVSSKIQDTKGCRACCV 618

  Fly   977 TRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIIT 1041
            .....:|..:||||..:.:.|:|||.|:|||:|::|..:|..:            ..|||.::.|
  Rat   619 AEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPT------------PLPVFALLTT 671

  Fly  1042 PELEYPIVCTGVR--KAMNGCLKLELINMNSAS-WFHSEDLEYDAMATMVPRRDLLKVVRVHQVE 1103
            |..|.|.||.||.  :|....| ...:...:.| |......|:..            .|:|.||:
  Rat   672 PGSELPAVCIGVSPGQAAKSVL-FHTVRFGALSCWLDDSSTEHKG------------PVQVIQVK 723

  Fly  1104 KDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEV 1168
            :|.::|.....:::||.:|.|....: ..::.....|:::..:.|.:.||.|||:|..:..:.:.
  Rat   724 EDMVMVLMDGSLKLVTPEGAPAPGLR-TPEIPMTEAVEAVAMVGDRLQAFWKHGVQVWAPDSEQP 787

  Fly  1169 TQEIKDMSRTYRLLGSDKVVALESQ 1193
            .||::|.:.|:|||.|.:.|.:|::
  Rat   788 LQELRDPTLTFRLLCSPRPVVVETR 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	171/257 (67%)
		S_TKc	26..283	CDD:214567	171/256 (67%)
		CNH	869..1184	CDD:279162	110/318 (35%)
Map4k1	NP_001099713.1	STKc_MAP4K3_like	16..274	CDD:270788	171/257 (67%)
		S_TKc	17..274	CDD:214567	171/256 (67%)
		CNH	506..813	CDD:214481	116/334 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780