DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and shk2

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_592864.1	Gene:	shk2 / 2541468	PomBaseID:	SPAC1F5.09c	Length:	589	Species:	Schizosaccharomyces pombe

Alignment Length:	278	Identity:	111/278 - (39%)
Similarity:	163/278 - (58%)	Gaps:	12/278 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNEL-----AAIKVIKLEPSDDIQIIQQE 71
            ||...::..:|.:.:.:..|:|.|..|.||.||.:...:|     .|||.|.|:.....::|..|
pombe   295 MLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNE 359

  Fly    72 IIMMRDCRHPNIIAYYGSYLRRDK-LWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLE 135
            |.:||:..||||:.|..|:|.|:: ||:.||:...|||.||.: ...|||.|||.:|.||.||::
pombe   360 ITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIE-KSKLTEAQIARICLETCKGIQ 423

  Fly   136 YLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGG 200
            :||:...:|||||..|:||...|::|:.|||..|:::...|||.:.:||||||||||.   ::..
pombe   424 HLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVV---KQNE 485

  Fly   201 YNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALT 265
            |....|||:.||..||:.|.:||.....|:|||:|::|:|  .|||...:..|....:|:.:.||
pombe   486 YGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNG--TPTLKKPNLVSKNLKSFLNSCLT 548

  Fly   266 KNPKKRPTAERLLQHPFV 283
            .:...|.||..||.|.|:
pombe   549 IDTIFRATAAELLTHSFL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	107/263 (41%)
		S_TKc	26..283	CDD:214567	107/262 (41%)
		CNH	869..1184	CDD:279162
shk2	NP_592864.1	PH_Cla4_Ste20	24..120	CDD:270097
		PBD	128..182	CDD:279166
		STKc_PAK	308..567	CDD:270789	108/265 (41%)
		S_TKc	309..566	CDD:214567	107/262 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910