DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Pak5

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_006499571.1	Gene:	Pak5 / 241656	MGIID:	1920334	Length:	736	Species:	Mus musculus

Alignment Length:	284	Identity:	108/284 - (38%)
Similarity:	163/284 - (57%)	Gaps:	6/284 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHP 81
            :|..:|::..:...|||.|:.|.|..|....:.:..|:|.:.|......:::..|:::|||..|.
Mouse   457 VSPGDPREYLDNFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 521

  Fly    82 NIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRD 146
            |::..|.|||..|:||:.|||..||:|.||...| .:.|.|||.:|...||.|.|||:.|.:|||
Mouse   522 NVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLKALSYLHNQGVIHRD 585

  Fly   147 IKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACG 211
            ||..:||||..|.:||:|||..||::..:.||||.:||||||||||.:   :..|....|||:.|
Mouse   586 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLG 647

  Fly   212 ITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAER 276
            |..||:.:.:||.|:..|::|:..:..|  .||.:.:..|.|.....|:...|.:.|.:|.||:.
Mouse   648 IMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQE 710

  Fly   277 LLQHPFVQCEMSLRVAKELLQKYQ 300
            ||.|||::..........|:::|:
Mouse   711 LLGHPFLKLAGPPSCIVPLMRQYR 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	103/257 (40%)
		S_TKc	26..283	CDD:214567	103/256 (40%)
		CNH	869..1184	CDD:279162
Pak5	XP_006499571.1	CRIB_PAK_like	26..72	CDD:238526
Pak5	XP_006499571.1	STKc_PAK5	443..734	CDD:132989	107/282 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910