DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and kin-18

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001022767.1	Gene:	kin-18 / 175862	WormBaseID:	WBGene00002201	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	144/550 - (26%)
Similarity:	241/550 - (43%)	Gaps:	109/550 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQ---IIQQEIIMMRDCR 79
            |.::|:..|:.:::||.|::|.||.|...::.:..|||.:.......::   .|.:|:..:....
Worm    22 SNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVV 86

  Fly    80 HPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMH 144
            ||:|:.|...:|:....|:.||:|.|.:...:..:...:.||:||.:|.:||..|.||||:.::|
Worm    87 HPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIH 151

  Fly   145 RDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWA 209
            ||||..||||:::..||||||| ||.:   ::..::|||||::|||||.....:|.|....|||:
Worm   152 RDIKAGNILLSDHAIVKLADFG-SASL---VDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWS 212

  Fly   210 CGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKD-----KWSPTFHNFIKTALTKNPK 269
            .|||.|||||.:||:|.::.|.||:.::::  .||||:..|     :||..|..||...|.|..:
Worm   213 LGITCIELAERRPPLFSMNAMSALYHIAQN--DPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAE 275

  Fly   270 KRPTAERLLQHPFVQCEMSLRVAKELLQK----------YQSPNPQFYYYLD------------- 311
            :|.:||...:|||:|........:||:|:          :|....:...|||
Worm   276 ERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLDETEGKEGSEGNGA 340

  Fly   312 -------GDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTG-----MTTNST-----------WN 353
                   |:|.:..|   |.....:||:..:.:......:|     ::||:|           :.
Worm   341 SDDLDFHGNEANSIG---RAGDSASSRSASLTSFRSMQSSGGAGLLVSTNTTGAMDNVHGSSGYG 402

  Fly   354 ERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGA 418
            ..|||..:                       :...:.|:.::...|:...|.......|.||...
Worm   403 NGSSSTTS-----------------------SARRRPPIPSQMLSSTSTSGVGTMPSHGSVGASI 444

  Fly   419 GGAAAN-------------GSSSSSGGATVGTTHHQ----------HQQHHQHHHHPNHLHQHQS 460
            ...|.|             .:|.|...:.:.|.|..          ...|..|......:...|:
Worm   445 TAIAVNPTPSPSEPIPTSQPTSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAVKERIATLQN 509

  Fly   461 HQLPQQQQQQSHQAAQQEHHHHHPMTSSIS 490
            |:....:.|:.....|:|:...:.|...:|
Worm   510 HKFATLRSQRIINQEQEEYTKENNMYEQMS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	99/265 (37%)
		S_TKc	26..283	CDD:214567	99/264 (38%)
		CNH	869..1184	CDD:279162
kin-18	NP_001022767.1	PKc_like	28..291	CDD:304357	100/268 (37%)
kin-18	NP_001022767.1	S_TKc	30..289	CDD:214567	99/264 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910