DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and MYO3B

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_011508956.1	Gene:	MYO3B / 140469	HGNCID:	15576	Length:	1386	Species:	Homo sapiens

Alignment Length:	391	Identity:	139/391 - (35%)
Similarity:	215/391 - (54%)	Gaps:	64/391 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDI-QIIQQ 70
            |:|..||..: |..:|.|.:|:|:.||.||||.|||....:...|||:|:  |:|..|: :.|:.
Human    18 HYNPMMLGLE-SLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKI--LDPVSDMDEEIEA 79

  Fly    71 EIIMMRDC-RHPNIIAYYGSYLRRD-----KLWICMEFCGGGSLQDIYQVTG------PLTEVQI 123
            |..:::.. .|||::.:||.:.:.|     :||:.:|.|.|||:.::  |.|      .|.|..|
Human    80 EYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTEL--VKGLLRCGQRLDEAMI 142

  Fly   124 AYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWM 188
            :|:....|.||::||:...:|||:||.|||||..|.|||.|||||||:|:|..:|.:.:|||:||
Human   143 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWM 207

  Fly   189 APEVAAVERK--GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDK 251
            ||||.|.|::  ..|:..||:|:.|||||||.:..||:||:||::.||.:.::  .||||.:.:|
Human   208 APEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN--PPPTLLHPEK 270

  Fly   252 WSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQ------CEMSLRVAKELL-QKYQSPNPQFYYY 309
            |...|::||...|.|:.::||:...||.|||::      ..:..::||.|. ||:|:|
Human   271 WCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNP------- 328

  Fly   310 LDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDE 374
                          :|.....|              |.|...::...:....|..|:..|:.:||
Human   329 --------------VAKTRHER--------------MHTRRPYHVEDAEKYCLEDDLVNLEVLDE 365

  Fly   375 E 375
            :
Human   366 D 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	115/272 (42%)
		S_TKc	26..283	CDD:214567	115/271 (42%)
		CNH	869..1184	CDD:279162
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	123/291 (42%)
		S_TKc	36..302	CDD:214567	115/271 (42%)
		MYSc	355..1062	CDD:214580	4/12 (33%)
		MYSc_Myo3	366..1055	CDD:276830	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910