Protein Alignment hppy and MAP4K5

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_006566.2
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 846
• Species: Homo sapiens
• Alignment Length: 1225
• Identity: 485/1225 - (39%)
• Similarity: 620/1225 - (50%)
• Gaps: 406/1225 - (33%)

  Fly    14 SSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDC 78
            ::||.|||||.:|||:|::|||||||||||:.:.:.||||:|:|||||.||..:|||||.|:::|
Human     8 AADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKEC 72

  Fly    79 RHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            :|.||:||:||||.|:|||||||:||||||||||.|||||:|:||||:|||||:||.|||:.|||
Human    73 KHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKM 137

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208
            ||||||||||||::||||||||||:|:|||||.||||||||||||||||||||:.||||||||||
Human   138 HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIW 202

  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273
            |.|||||||.|||||||||||||||||||||.|:||.|.:|.|||.|||||:|.|||||||||||
Human   203 AVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPT 267

  Fly   274 AERLLQHPFV-QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337
            |||||.|.|| |..:|..:|.|||.|..:|: ...:|.:.|::...  |..|.
Human   268 AERLLTHTFVAQPGLSRALAVELLDKVNNPD-NHAHYTEADDDDFE--PHAII------------ 317

  Fly   338 QNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHN 402
             .||::   :||     |::..|...|:::.     ::|:....|....:.:|.:|....
Human   318 -RHTIR---STN-----RNARAERTASEINF-----DKLQFEPPLRKETEARDEMGLSSD----- 363

  Fly   403 GGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQ 467
                                                             ||.:.|
Human   364 -------------------------------------------------PNFMLQ---------- 369

  Fly   468 QQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFG 532
                          .:|.....::|..|:..   :....|...|.:|:|
Human   370 --------------WNPFVDGANTGKSTSKR---AIPPPLPPKPRISSY---------------- 401

  Fly   533 MGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSAS---AAHYLRYSSN 594
                       ..|...||..|:.:                     ..|..|   |...||..|:
Human   402 -----------PEDNFPDEEKASTI---------------------KHCPDSESRAPQILRRQSS 434

  Fly   595 YRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNG 659
            ......|:                        ||||                          |||
Human   435 PSCGPVAE------------------------TSSI--------------------------GNG 449

  Fly   660 GGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSS 724
            .|.|.:.|
Human   450 DGISKLMS--------------------------------------------------------- 457

  Fly   725 SNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPR 789
                            |...||:.|
Human   458 ----------------ENTEGSAQA---------------------------------------- 466

  Fly   790 TRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKI 854
                                        |..|::..||..  |:|..|||||||||.|||||||:
Human   467 ----------------------------PQLPRKKDKRDF--PKPAINGLPPTPKVLMGACFSKV 501

  Fly   855 FNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMS 919
            |:||||:::|..|||||:|:||:::.|.|:|||.||:||||:|.::|||||:.||||||.:.|||
Human   502 FDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMS 566

  Fly   920 LS-GKSCQLYRHDLVAL--HSK--------QTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQ 973
            || ||:.|||.|:|:||  |:|        ||.||       |:|::|||||||||:||||.|.:
Human   567 LSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRF-------PDRILPRKFALTTKIPDTKGCHK 624

  Fly   974 CCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTP--VF 1036
            ||:.||||.|:||||||..|||.|:|||:|:.||||:|..::|..|              |  ||
Human   625 CCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPS--------------PLNVF 675

  Fly  1037 EMIITPELEYPIVCTGVRKA--MNGCLKLELINMNSA-SWFHSEDLEYDAMATMVPRRDLLKVVR 1098
            ||::.||.|||:||..:.|.  .|..::.|.||:||| |||    .|..|.:..      |..:.
Human   676 EMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF----TEIGAGSQQ------LDSIH 730

  Fly  1099 VHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSL 1163
            |.|:|:|.:|||....:::|.|||..|..||:.|:|:|||.::|:|||.||||||.||||||||.
Human   731 VTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSF 795

  Fly  1164 RNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218
            ::.||||||.|.:|.:||||||:||.|||:.....:..|    :||||||||.||
Human   796 KSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHS----NLYILAGHENSY 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	202/257 (79%)
		S_TKc	26..283	CDD:214567	202/256 (79%)
		CNH	869..1184	CDD:279162	167/330 (51%)
MAP4K5	NP_006566.2	STKc_MAP4K5	10..277	CDD:270813	209/266 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..485		50/493 (10%)
		CNH	511..826	CDD:214481	178/345 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	451	1.000	Domainoid score	I511
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	901	1.000	Inparanoid score	I381
Isobase	1	0.950	-	0	Normalized mean entropy	S2065
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm40262
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4905
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820