DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and PAK4

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001014831.1	Gene:	PAK4 / 10298	HGNCID:	16059	Length:	591	Species:	Homo sapiens

Alignment Length:	263	Identity:	106/263 - (40%)
Similarity:	158/263 - (60%)	Gaps:	6/263 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIA 85
            :|:...:...|||.|:.|.|..|....|.:|.|:|.:.|......:::..|:::|||.:|.|::.
Human   316 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVE 380

  Fly    86 YYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGA 150
            .|.|||..|:||:.|||..||:|.||...| .:.|.|||.:|...|:.|..||:.|.:|||||..
Human   381 MYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 444

  Fly   151 NILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAI 215
            :||||..|.|||:|||..||::..:.:|||.:|||||||||:.:   :..|....|||:.||..|
Human   445 SILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLPYGPEVDIWSLGIMVI 506

  Fly   216 ELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQH 280
            |:.:.:||.|:..|::|:.::..:  .||.|.|..|.||:...|:...|.::|.:|.||..||:|
Human   507 EMVDGEPPYFNEPPLKAMKMIRDN--LPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKH 569

  Fly   281 PFV 283
            ||:
Human   570 PFL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	104/257 (40%)
		S_TKc	26..283	CDD:214567	104/256 (41%)
		CNH	869..1184	CDD:279162
PAK4	NP_001014831.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..301
		GEF-interaction domain (GID)	298..323		1/6 (17%)
		STKc_PAK4	300..591	CDD:132988	106/263 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910