Protein Alignment hppy and map4k3

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_012818238.1
• Gene: map4k3 / 100170570
• XenbaseID: XB-GENE-951441
• Length: 924
• Species: Xenopus tropicalis
• Alignment Length: 1240
• Identity: 501/1240 - (40%)
• Similarity: 638/1240 - (51%)
• Gaps: 358/1240 - (28%)

  Fly    16 DISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRH 80
            |:||||||:::||||:||||||||||||:.:.:.||||||||||||.:|..::|||||||:||:|
 Frog     6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70

  Fly    81 PNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHR 145
            .||:||:|||||||||||||||||||||||||.|||||:|.||||:.||||:||.||||.|||||
 Frog    71 TNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSEQQIAYVSRETLQGLYYLHSKGKMHR 135

  Fly   146 DIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAC 210
            ||||||||||:.|.||||||||||||||||.|||||||||||||||||||||||||||||||||.
 Frog   136 DIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAV 200

  Fly   211 GITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAE 275
            |||:||||||||||||||||||||||:||.|:||.|.:|.|||.:||:|||.|||||||||||||
 Frog   201 GITSIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFIKMALTKNPKKRPTAE 265

  Fly   276 RLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEE--------SVAGVPQRIASKMTSRT 332
            :||||||:...::..:|.|||.|..:|:...::..|.|:.        |.|..|.|.|.:..:|.
 Frog   266 KLLQHPFLTQPLNRTLAIELLDKVNNPDHSSFHDFDDDDPEFKFWGIFSPASPPVRRAPRFAARP 330

  Fly   333 NGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECS 397
            ..:....|.:      :||  .||...|...|:::..|       ::...||..:|
 Frog   331 KPMVVVPHRI------HST--SRSVREEKTRSEINFGQ-------IKFDPPLRKET--------- 371

  Fly   398 CSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQ 462
                                                                             
 Frog   372 ----------------------------------------------------------------- 371

  Fly   463 LPQQQQQQSHQAAQQEHHH----HHPMTSSISSGLVTANAN-------------NISSSASLASM 510
                           |.||    ...:..|......||.:|             |....|:.:.:
 Frog   372 ---------------EPHHDLLDRDDLLDSAEDIYYTARSNLDLQLEYGQGPQSNYFLGANKSLL 421

  Fly   511 PGLSAYLGMRSHVVGHMGMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGN 575
            ..:...|..|.| |.|:               ...|.||||...:.:.........|
 Frog   422 KSVEEELHQRGH-VAHL---------------EDDDGDDDESKHSTIKPKVPPPLPP-------- 462

  Fly   576 GSGSGCSASAAHYLRYSSNYRSAAAAQASQAAHPHVNSNSNSNNGH-GHAPITSSISSSASSASF 639
                              ..:|....|.|       |::.:.|.|. ...|::.|::..||....
 Frog   463 ------------------KPKSIYIPQES-------NASEDDNQGTIKRCPVSESLARPASYVPP 502

  Fly   640 YNRLLLLDNSSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNS 704
            ......|.....:|:  |||.||.::          ||  || |:.:|.|
 Frog   503 RPPPPRLPPHKPNAL--GNGVGSFHL----------NG--DK-EMSSLSQ--------------- 537

  Fly   705 PTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPR 769
                                                                ...|||
 Frog   538 ----------------------------------------------------QSENQN------- 543

  Fly   770 RHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRP 834
                                ::||                     |.|      :.|.:...|:|
 Frog   544 --------------------SKSL---------------------NLP------TRKDKKDVPKP 561

  Fly   835 ISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAI 899
            |||||||||||||||||||:||||||::||..|||:||||||:|:.|||||||.||:||||:.::
 Frog   562 ISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPETRDQYLIFGAEEGIYTLNLNELHETSM 626

  Fly   900 DQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVAL----HSKQTVRFSLHMNKIPERLVPRKFA 960
            :||||||.|||||:.:.|:|:|||:.|||.|:|..:    ...|.:..|:..:|:|:|::|||||
 Frog   627 EQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGIFDYARQMQKLPVSIPAHKLPDRILPRKFA 691

  Fly   961 LTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGH 1025
            ::||:||||.|.:|||.||||..:||||||..|.|.|::|.:|:.||||:|..::|
 Frog   692 VSTKIPDTKWCQKCCVVRNPYTSHKYLCGALQSSIVLLEWVEPMQKFMLIKHIDFP--------- 747

  Fly  1026 GCVQNGHTP----VFEMIITPELEYPIVCTGVRKA--MNGCLKLELINMNS-ASWFHSEDLEYDA 1083
                   .|    :.||::.||.|||:||..|.|.  .|..::.|.:|.|| :|||...|.....
 Frog   748 -------LPCPLMLLEMLVVPEHEYPLVCVSVSKGTDFNQVVRFETVNPNSTSSWFTETDTPQSG 805

  Fly  1084 MATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPD 1148
                        ||.|.|:|:|.||||....|::|.|||..|..:|:.|:|.|||.::|||||.|
 Frog   806 ------------VVHVTQLERDTILVCLDRCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQD 858

  Fly  1149 SVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAG 1213
            |||||.||||||:|.|:.|:||||.|.:|.:||||||:||.|||:.....:..|    :||||||
 Frog   859 SVLAFWKHGMQGRSFRSNEITQEISDSTRIFRLLGSDRVVVLESRPTDNPTANS----NLYILAG 919

  Fly  1214 HEASY 1218
            ||.||
 Frog   920 HENSY 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	211/257 (82%)
		S_TKc	26..283	CDD:214567	211/256 (82%)
		CNH	869..1184	CDD:279162	155/325 (48%)
map4k3	XP_012818238.1	STKc_MAP4K3_like	15..272	CDD:270788	210/256 (82%)
		S_TKc	16..273	CDD:214567	211/256 (82%)
		CNH	591..904	CDD:214481	166/340 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I523
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2683
Inparanoid	1	1.050	889	1.000	Inparanoid score	I387
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm47435
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4905
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110