DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and stk3

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001090665.1	Gene:	stk3 / 100036637	XenbaseID:	XB-GENE-960732	Length:	493	Species:	Xenopus tropicalis

Alignment Length:	425	Identity:	158/425 - (37%)
Similarity:	232/425 - (54%)	Gaps:	56/425 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            ||.|...:.|::.:::::|:|.|:||.|:||...:|.::.|||.:.:|  .|:|.|.:||.:|:.
Frog    13 LSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIMQQ 75

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLTEVQIAYMCRETLKGLEYLHSMG 141
            |....::.|||||.:...|||.||:||.||:.||.::.. .|||.:||.:.|.|||||||||.|.
Frog    76 CDSHYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATILRSTLKGLEYLHFMR 140

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |:|||||..||||...|..|||||||:.|:|.|:.||.:.||||:||||||.   ::.|||.:.|
Frog   141 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVAD 202

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            ||:.|||:||:||.:||..|:|||||:|::..:  .|||....:.||..|.:|:|..|.|||::|
Frog   203 IWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDEFTDFVKKCLVKNPEQR 265

  Fly   272 PTAERLLQHPFVQCEMSLRVAKELL--------QKYQSPNPQFYYYLDGDEESVAGVPQRIASKM 328
            .||.:||||.|::....:.:.::|:        ::::....:.      :||........:.|..
Frog   266 ATATQLLQHSFIKNAKPVSILRDLITEAMDIKAKRHEEQQREL------EEEDENSEEDELDSHT 324

  Fly   329 TSRTN----GVPAQNHTLKTGMTT----NSTWNERSSSPETLPSDMSLLQYIDEE--------LK 377
            ..:||    |......|:..|..|    |||..|.......:.||       |||        :|
Frog   325 MVKTNSESAGTMRAASTMSEGAQTMIEHNSTMLESDLGTMVINSD-------DEEEEEEEDGTMK 382

  Fly   378 LRATLPL-----------NNDTKDPLGAECSCSSH 401
            ..||.|.           ..|:|......|:.:.|
Frog   383 RNATSPQVPRPSFMDYFDKQDSKSKPHDNCNQNLH 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	126/258 (49%)
		S_TKc	26..283	CDD:214567	126/257 (49%)
		CNH	869..1184	CDD:279162
stk3	NP_001090665.1	STKc_MST1_2	22..277	CDD:132943	127/261 (49%)
stk3	NP_001090665.1	Mst1_SARAH	439..486	CDD:314497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910