Protein Alignment hppy and map4k3b

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_009291338.1
• Gene: map4k3b / 100005183
• ZFINID: ZDB-GENE-090428-1
• Length: 897
• Species: Danio rerio
• Alignment Length: 1225
• Identity: 484/1225 - (39%)
• Similarity: 636/1225 - (51%)
• Gaps: 349/1225 - (28%)

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            ||.|:||||||:::||||:||||||||||||:.:.:.||||||||||||.:|..::|||||||:|
Zfish     3 LSLDLSRRNPQEDFELIQRIGSGTYGDVYKARNVSTGELAAIKVIKLEPGEDFDVVQQEIIMMKD 67

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGK 142
            |:|.||:||:|||||||||||.||:||||||||||.|||||:|.||||:|||||:|:.|||:.||
Zfish    68 CKHSNIVAYFGSYLRRDKLWISMEYCGGGSLQDIYHVTGPLSESQIAYVCRETLQGVYYLHNKGK 132

  Fly   143 MHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 207
            :||||||||||||:.|.||||||||||||:||:.|||||||||||||||||||||||||||||||
Zfish   133 IHRDIKGANILLTDNGYVKLADFGVSAQISATLAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 197

  Fly   208 WACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRP 272
            ||.||||||||||:|||||||||||||||:||.|:||.|.:|.||:..||:|:|.||||||||||
Zfish   198 WAVGITAIELAELEPPMFDLHPMRALFLMTKSSFQPPKLKDKVKWTNNFHHFVKMALTKNPKKRP 262

  Fly   273 TAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDE-----ESVAGVPQRIASKMTSRT 332
            ||:||||||||...:|..:|.|||.|  :.||....:.|.:|     ||...||.||.|  |||:
Zfish   263 TADRLLQHPFVTQPLSRTLAIELLDK--ANNPDHSTHSDAEEDDIDPESPVSVPHRIRS--TSRS 323

  Fly   333 NGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECS 397
            :         :.|.|                     |..|:.: |::...||..:|
Zfish   324 S---------RDGKT---------------------LSEINFD-KVKFDPPLRKET--------- 348

  Fly   398 CSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQ 462
                                                         :.||:             ..
Zfish   349 ---------------------------------------------EPHHE-------------MD 355

  Fly   463 LPQQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHM 527
            ||.:.|                          :...||.|...|:|.      .|..|.||. |:
Zfish   356 LPLEPQ--------------------------SILGNNKSLLKSVAE------ELNQRGHVT-HL 387

  Fly   528 GMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYS 592
            .                 |.::||                        |....|::::
Zfish   388 E-----------------DEEEDE------------------------GDDLHCNSTS------- 404

  Fly   593 SNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGG 657
                         ...|.|..         ..|....:.|.|.|:|
Zfish   405 -------------TMRPKVPP---------PLPPKPKVLSPAQSSS------------------- 428

  Fly   658 NGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGP 722
                    :|...:..||        :...|.:|          |::|.|.    .|.......|
Zfish   429 --------ASEDNSGEGT--------IKRCPASA----------SSTPPAR----PTSCVPPRPP 463

  Fly   723 SSSNSSHLYQNLLRSSSGETP---AGSSSAGNNCDYR-----HENNQNGLEDSPRRHSSMDQLIG 779
            ......|     .|||.|:.|   |.:..||::..||     |...|       ..||:
Zfish   464 PPRLPPH-----RRSSLGKKPSEHAQTEPAGDDGIYRFWEWLHAEEQ-------EEHSN------ 510

  Fly   780 LLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPK 844
                             |....:..:||....|        |..|.:      .|.|||||||||
Zfish   511 -----------------GVSSPENGDKEKLASL--------PSCSLQ------LPFSNGLPPTPK 544

  Fly   845 VHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTW 909
            |||||||||:||||||::||..|||:|.||||:|:.|||||||.||:||:|::.::||.|||.||
Zfish   545 VHMGACFSKVFNGCPLKIHCACSWINPNTRDQYLIFGAEEGIYTLNLNEIHESTMEQLVPRRCTW 609

  Fly   910 LYVIKDVLMSLSGKSCQLYRHDLVALHSK----QTVRFSLHMNKIPERLVPRKFALTTKVPDTKC 970
            :||:.:.|:|:|||:.|||.::|..|..:    |.:..::..:|:|::::||||.::.|:|:|:.
Zfish   610 VYVMNNWLLSISGKASQLYSYNLTGLFEQARQMQKLPVAIPTHKLPDKIIPRKFTVSNKIPETRG 674

  Fly   971 CTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPV 1035
            |.:|||.||||.|:||||||..|.:.|.:|.:.:.:|||:|..|   :::.     |    ...|
Zfish   675 CQKCCVVRNPYTGHKYLCGAFQSSVMLFEWVEAMQRFMLIKSIE---LTLP-----C----PLEV 727

  Fly  1036 FEMIITPELEYPIVCTGVRKAM--NGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVR 1098
            |||::.||..||:||..|.|..  :..:....::.|:.:...:|           |......|:.
Zfish   728 FEMLVVPEQHYPVVCVAVSKGSHPDQVVTFGTVDPNAGNPTFTE-----------PETPQTCVIH 781

  Fly  1099 VHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSL 1163
            |.|:|:|.:|||....|::|.|||..|.:||:.::|.|:|.:::||||.||||||.||||||:|.
Zfish   782 VTQLERDTVLVCLDRCIKLVNLQGRLKSNKKLSTELTFNFQIEAIVCLQDSVLAFWKHGMQGRSF 846

  Fly  1164 RNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218
            :|.|:||||.|.||||||||:|:||.|||:.....:..|    :||||||||.||
Zfish   847 KNSEITQEISDNSRTYRLLGADRVVVLESKPTEDPTAQS----NLYILAGHENSY 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	203/257 (79%)
		S_TKc	26..283	CDD:214567	203/256 (79%)
		CNH	869..1184	CDD:279162	137/320 (43%)
map4k3b	XP_009291338.1	STKc_MAP4K3	4..275	CDD:270812	213/270 (79%)
		CNH	564..877	CDD:214481	147/335 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I542
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2683
Inparanoid	1	1.050	876	1.000	Inparanoid score	I387
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm25498
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.880