DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hppy and taok1a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_001343838.1	Gene:	taok1a / 100004576	ZFINID:	ZDB-GENE-130103-9	Length:	1023	Species:	Danio rerio

Alignment Length:	535	Identity:	158/535 - (29%)
Similarity:	249/535 - (46%)	Gaps:	100/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKL---EPSDDIQIIQQEIIMMRDCRH 80
            :.:|:..:..:::||.|::|.||.|:.::::|:.|||.:..   :.::..|.|.:|:..::..:|
Zfish    21 KEDPERLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQRIKH 85

  Fly    81 PNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQV-TGPLTEVQIAYMCRETLKGLEYLHSMGKMH 144
            ||.|.|.|.|||....|:.||:| .||..|:.:| ..||.|::||.:....|:||.||||...:|
Zfish    86 PNSIEYKGCYLREHTAWLVMEYC-LGSTSDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIH 149

  Fly   145 RDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWA 209
            ||||..||||||.|.||||||| ||.|.:..|   ||:||||||||||.....:|.|:...|||:
Zfish   150 RDIKAGNILLTEPGQVKLADFG-SASIASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDIWS 210

  Fly   210 CGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTA 274
            .|||:|||||.:||:|:::.|.||:.::::  :.|:|.:.: |:..|.||:.:.|.|.|:.||.:
Zfish   211 LGITSIELAERKPPLFNMNAMSALYHIAQN--ESPSLQSSE-WTDYFRNFVDSCLQKLPQDRPHS 272

  Fly   275 ERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQN 339
            |.||:|.|||.|.                                 |:.:...:..||.....:.
Zfish   273 EELLKHAFVQRER---------------------------------PESVLIDLIQRTKDAVREL 304

  Fly   340 HTLKTGMTTNSTWNERSSSPET-LPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNG 403
            ..|::.......:.|..:.|.. :|.|       :||::                       |:.
Zfish   305 DNLQSRKMKKILFQEAHNGPAVEVPDD-------EEEVE-----------------------HSV 339

  Fly   404 GAAGGGGGGGVGVGAGGAAANGSSSSSG-----GATVGTTHHQHQQHHQHHHH---PNH--LH-- 456
            |..|.....|........:.:.||.||.     .||..|..::.:........   ||.  :|
Zfish   340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDATDATDDNKSEVDLMEKDQTIIPNSSIIHVK 404

  Fly   457 -QHQSHQLPQQQQQQ--------SHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPG 512
             :.:|:|...:.|:|        :|...:|..:..|..|...:| |||.........:.:...
Zfish   405 PEEESYQEETEVQKQPTEPQSPPAHTPRRQYRNREHFATIRTAS-LVTRQIQEHEQDSEVREQ-- 466

  Fly   513 LSAYLGMRSHVVGHM 527
            :|.|..||.....|:
Zfish   467 MSGYKRMRRQHQKHL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	112/261 (43%)
		S_TKc	26..283	CDD:214567	112/260 (43%)
		CNH	869..1184	CDD:279162
taok1a	XP_001343838.1	PKc_like	2..318	CDD:304357	121/337 (36%)
taok1a	XP_001343838.1	S_TKc	28..281	CDD:214567	112/260 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910