DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10737 and C2CD2L

DIOPT Version :9

Sequence 1:	NP_001137711.1	Gene:	CG10737 / 37202	FlyBaseID:	FBgn0034420	Length:	955	Species:	Drosophila melanogaster
Sequence 2:	NP_055622.3	Gene:	C2CD2L / 9854	HGNCID:	29000	Length:	707	Species:	Homo sapiens

Alignment Length:	796	Identity:	151/796 - (18%)
Similarity:	265/796 - (33%)	Gaps:	207/796 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LAGASGGRGRSSASPLNTAGAAAGGPR-----RRVVRQSSTGPENRKKRYVPPPSNVVGPETSSV 166
            ||.|.|.||...|    .||..||..|     |.::|..:|      :........|.|...|..
Human    39 LARARGDRGPGPA----LAGEPAGSLRELGVWRSLLRLRAT------RAGAAEEPGVRGLLASLF 93

  Fly   167 TWTSQVFRWLYSDLVIVNELLMSWVIAINDTLRKSVEEHGVAVEVVRVLPDSPAPGLNNIFCNCD 231
            .:.|....|           ..:||.|:|:...::.....:|.|.|..||  |...::::  .|.
Human    94 AFKSFRENW-----------QRAWVRALNEQACRNGSSIQIAFEEVPQLP--PRASISHV--TCV 143

  Fly   232 ENNPADMLITFDCDAMPV-LQVKTFRQKSGKVETSHYKVTVSRFRARMAIPMNYNSLKGEMRVEG 295
            :.:...|::.....|..| ..|...:|....|....|.||::....::.:  |...:.||..:..
Human   144 DQSEHTMVLRCQLSAEEVRFPVSVTQQSPAAVSMETYHVTLTLPPTQLEV--NLEEIPGEGLLIS 206

  Fly   296 Y-----PDVRIAMNSVGAIKAMDQDEQQLQ-TVISDILTTALRDTIYPVDFSIYSTCPRAEVEPL 354
            :     ||  :::..:..::|.::.|:|:: :.|.:::..|:..|...:..::.:......:.|.
Human   207 WAFTDRPD--LSLTVLPKLQARERGEEQVELSTIEELIKDAIVSTQPAMMVNLRACSAPGGLVPS 269

  Fly   355 DLPVIYPVHYDSLAHNMEQHMGGVGLRDSQHMVSGRRLLVKIVK----GDGIRDAQNPYVVIEMD 415
            :.|.:.|....::..                   ..||.::.::    |:.:...:....|.|:|
Human   270 EKPPMMPQAQPAIPR-------------------PNRLFLRQLRASHLGNELEGTEELCCVAELD 315

  Fly   416 EPAQKNQTGTQRGGKPF-WDEHFLFELSPQSAEILFEVYDHPVIASDPPKFLGLGLVGIDELAVG 479
            .|.|:..|...|.|... |.|....:|.|||.|:..:|..........       |:|...|.||
Human   316 NPMQQKWTKPARAGSEVEWTEDLALDLGPQSRELTLKVLRSSSCGDTE-------LLGQATLPVG 373

  Fly   480 PAS-----TQLLQLQPRPYETQPVSGAITVDFVFIEGAEIPAGARPQRLKEALRLSTPAINEHIR 539
            ..|     .||..|.|.|.:....:..:.|:..:.||:       |:.|
Human   374 SPSRPLSRRQLCPLTPGPGKALGPAATMAVELHYEEGS-------PRNL---------------- 415

  Fly   540 NGADLADAAVRALQDGALSSSGSGGQPSKSTLIIHSVQRNSSSPNAFKVELNR----DGQIEVTD 600
                                    |.|:.||      .|.|.:|.. |:||:|    ||.|..|.
Human   416 ------------------------GTPTSST------PRPSITPTK-KIELDRTIMPDGTIVTTV 449

  Fly   601 TATELDQAVAQAFERAANEAQTELELELAKEEKSSQLGEPLIDSGNGTVNEESTAEFGQPNAASS 665
            |..:                        ::.....:|..|........|.|::|....:.:..|:
Human   450 TTVQ------------------------SRPRIDGKLDSPSRSPSKVEVTEKTTTVLSESSGPSN 490

  Fly   666 PNGSSYHNNYSLNGNGNSNGAGSGGYNSLPRNGGAQQLAQQSGLLEGHDVVDDRGRSKKRNFFGT 730
            .:.||...:..|     |||.......::      :||.:.||.:
Human   491 TSHSSSPGDSHL-----SNGLDPVAETAI------RQLTEPSGRV-------------------- 524

  Fly   731 LKKRLSRSKTRTLSADQPNNNSHKSLSATNSNTTTATGFPRTATGTLNGDSSRSLSVDRATLSKS 795
            .||..::..|..:|.......:...|:.:.....:.....:...||..|.||........:....
Human   525 AKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASVQDDAGTSGGPSSPPSDPPAMSPGPL 589

  Fly   796 NSLGPRMGIGHSITDHSRRSSISESSAISGFSSASNKTYVHEASTLVLETIENGIKRHFI----- 855
            ::|.....:..:  |.:.||.|||..::....|.:       .||..|||  ..:|.|.:
Human   590 DALSSPTSVQEA--DETTRSDISERPSVDDIESET-------GSTGALET--RSLKDHKVSFLRS 643

  Fly   856 -VPLAIAQRPRWRRKG 870
             ..|...:|||.:..|
Human   644 GTKLIFRRRPRQKEAG 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10737	NP_001137711.1	C2_C21orf25-like	392..515	CDD:176060	32/132 (24%)
CG10737	NP_001137711.1	C1	879..930	CDD:237996
C2CD2L	NP_055622.3	C2	300..412	CDD:301316	30/125 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..430		10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..636		19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..683		4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NK6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21119
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930