DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10737 and C2cd2l

DIOPT Version :9

Sequence 1:	NP_001137711.1	Gene:	CG10737 / 37202	FlyBaseID:	FBgn0034420	Length:	955	Species:	Drosophila melanogaster
Sequence 2:	XP_006242979.1	Gene:	C2cd2l / 300666	RGDID:	1310281	Length:	708	Species:	Rattus norvegicus

Alignment Length:	775	Identity:	147/775 - (18%)
Similarity:	261/775 - (33%)	Gaps:	221/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GLDLSKPLAGASGGRGRSSASPLNTAGAAAG-GPRRRVVRQSSTGPENRKKRYVPPPSNVVGPET 163
            ||.||:    |.|||....||.....|:... |..|.::|..:|      :...|..:.|.|...
  Rat    36 GLWLSR----AGGGRDSRPASAAEPGGSLRELGVWRSLLRLRAT------RSSAPEEAGVRGLLA 90

  Fly   164 SSVTWTSQVFRWLYSDLVIVNELLMSWVIAINDTLRKSVEEHGVAVEVVRVLPDSPAPGLNNIFC 228
            |...:.|....|           ..:||.|:|:...:......:|.|.:..||  |...::::
  Rat    91 SLFAFKSFRENW-----------QRAWVRALNEQACRDGSSIQIAFEEIPQLP--PRASISHV-- 140

  Fly   229 NCDENNPADMLITFDCDAMPV-LQVKTFRQKSGKVETSHYKVTVSRFRARMAIPMNYNSLKGEMR 292
            .|.:.:...|::.....|..| ..:...:|....|....|.||::....::.:.:.      |:.
  Rat   141 TCVDQSERTMVLHCQLAAEEVRFPISVTQQSPAAVSMETYHVTLTLPPTQLEVSLE------EIP 199

  Fly   293 VEGY---------PDVRIAMNSVGAIKAMDQDEQQLQTVISDILTTALRDTIYPVDFSIYSTCPR 348
            .||.         ||:.:.:......:..|:::.:|.|| .:::..|:..|...:..::.:....
  Rat   200 DEGLLVSWAFTDRPDLSLKVLPKSQTRERDEEQPELSTV-EELIKDAIVSTQPAMMVNLRACSAP 263

  Fly   349 AEVEPLDLPVIYPVHYDSLAHNMEQHMGGVGLRDSQHMVSGRRLLVKIVK----GDGIRDAQNPY 409
            ..:.|.:.|           ..|.|....:        ....||.::.::    |..:...:...
  Rat   264 GGLVPSEKP-----------PTMSQAQPSI--------PRPTRLFLRQLRASHLGSELGGTEELC 309

  Fly   410 VVIEMDEPAQKNQT-GTQRGGKPFWDEHFLFELSPQSAEILFEVYDHPVIASDPPKFLGLG---L 470
            ...|:|.|.|:..| .|:.|.:..|.|....:|.|||.|:..:|.          :....|   |
  Rat   310 CAAELDNPMQQKWTKPTRAGSEVEWAEDLALDLGPQSRELTLKVL----------RSSSCGDAEL 364

  Fly   471 VGIDELAVGPAS-----TQLLQLQPRPYETQPVSGAITVDFVFIEGAEIPAGARPQRLKEALRLS 530
            :|...|.||..|     .|:..|.|.|.::...:..:||:..:.:|:       |:.|
  Rat   365 LGQATLPVGSPSKPLSRRQVCPLTPGPGKSLSPAAIVTVELHYEQGS-------PRNL------- 415

  Fly   531 TPAINEHIRNGADLADAAVRALQDGALSSSGSGGQPSKSTLIIHSVQRNSSSPNAFKVELNR--- 592
                                             |.|:.||      .|.|.:|.. |:||:|
  Rat   416 ---------------------------------GTPTSST------PRPSITPTK-KIELDRTIM 440

  Fly   593 -DGQIEVTDTATE----LDQAVAQAFERAANEAQTELELELAKEEK--------SSQLGEPLIDS 644
             ||.|..|.|..:    :|..:|.:..|:.::.:...::.....|.        ||..||..:.:
  Rat   441 PDGTIVTTVTTVQSRPRVDGKLADSPSRSPSKVEVTEKMTTVLSESSGPSNASHSSSPGESHLSN 505

  Fly   645 GNGTVNEESTAEFGQPNAASSPNGSSYHNNY-----------------------SLNGNGNSNGA 686
            |...|.|.:..:..:|:..::....:..:..                       ||..:...:..
  Rat   506 GLDPVAETAIRQLTEPSGRAAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASMQDDAG 570

  Fly   687 GSGGYNSLPRN------GGAQQLAQQSGLLEGHDV----------VDD-----------RGRSKK 724
            .|||.:|.|.:      |....|:..:.:.|..:.          |||           ..||.|
  Rat   571 ASGGPSSPPSDPSATSPGPVDALSSPTSVQEADETTRSDISERPSVDDVESETGSTGALETRSLK 635

  Fly   725 RNFFGTLKKRLSRSKTRTLSADQPN------NNSHKSLSATNSNTTTATGFPRTATGTLN 778
            .:     |....||.|:.:...:|.      :.||..||     .||||...|...|:.:
  Rat   636 DH-----KVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLS-----NTTATPSVRKKAGSFS 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10737	NP_001137711.1	C2_C21orf25-like	392..515	CDD:176060	31/135 (23%)
CG10737	NP_001137711.1	C1	879..930	CDD:237996
C2cd2l	XP_006242979.1	C2	288..412	CDD:301316	31/140 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NK6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21119
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930