DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10737 and C2CD2

DIOPT Version :9

Sequence 1:	NP_001137711.1	Gene:	CG10737 / 37202	FlyBaseID:	FBgn0034420	Length:	955	Species:	Drosophila melanogaster
Sequence 2:	XP_011527824.1	Gene:	C2CD2 / 25966	HGNCID:	1266	Length:	707	Species:	Homo sapiens

Alignment Length:	767	Identity:	145/767 - (18%)
Similarity:	251/767 - (32%)	Gaps:	237/767 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PRRRVVRQSSTGPENRKKRYVPPPSNVVGPETSSVTWTSQVFRWLYSDLVIVNELLMSWVIAIND 196
            |:||.| :...||.        |.|:.:      ::|...:..|.       ::...:||.|:|:
Human    45 PQRRAV-EPGEGPR--------PGSDAL------LSWILTLGSWR-------SQWQAAWVTALNE 87

  Fly   197 TLRK-------SVEE--HGVAVE--------VVRVLPDSPAPGLNN-----IFCNCDENNPADML 239
            ...:       |.||  ...|:|        |:|...:..:||.::     :.|:.     ....
Human    88 EAERKGGPPFLSFEEDPRQQALELVVQEVSSVLRSAEEKVSPGAHSLQEEVVVCHV-----VGQA 147

  Fly   240 ITFDCDAMPVLQVKTFRQKSGKVETSHYKVTVSRFRARMAIPMNYNSLKGEMRVEGYPDVRIAMN 304
            |.|.....|.|          ......|.:.:|.|..::...|.          |...|::|:.:
Human   148 IQFLVSETPAL----------GAGCRLYDMRLSPFHLQLEFHMK----------EKREDLQISWS 192

  Fly   305 SVG----AI----KAMDQDEQQLQTVISDILTTALRDTIYPVDFS-IYSTCPRAEVEPLDLPVIY 360
            .:.    |:    ||:.:|:....:.:||:|...|:........| :..|.|....|..:|....
Human   193 FISVPEMAVNIQPKALGEDQVAETSAMSDVLKDILKHLAGSASPSVVLITKPTTVKEAQNLQCAA 257

  Fly   361 PVHYDSL------AHNMEQHMGGVGLRDSQHMVSGRRLLVKIVKGDGIRDAQNPYVVIEMDEPAQ 419
            ....:|.      ||.::              :..|.:.|.::...|.....|...|:::::|.|
Human   258 STAQESCPPKPPRAHELK--------------LLVRNIHVLLLSEPGASGHINAVCVVQLNDPVQ 308

  Fly   420 K-NQTGTQRGGKPFWDEHFLFELSPQSAEILFEVYDHPVIASDPPKFLGLGLVGIDELAVGPAST 483
            : :.|.|:......|:|.|.|||:.:|.|:..::.:   ........|....|.:|.....|:..
Human   309 RFSSTLTKNTPDLMWEEEFTFELNAKSKELHLQISE---AGRSSEGLLATATVPLDLFKKQPSGP 370

  Fly   484 QLLQLQPRPYETQPVSGAITVDFVFIEGAEI---------------------PAG---------- 517
            |...|.........|.|::|.:|.::|..|:                     |.|
Human   371 QSFTLTSGSACGSSVLGSVTAEFSYMEPGELKSWPIPPPVPAAKIEKDRTVMPCGTVVTTVTAVK 435

  Fly   518 -------ARPQRLKEALRLSTP----AINEHIR-------------------------NGAD-LA 545
                   .|...|.....:.||    .|.:.|.                         ||:| :|
Human   436 TKPRVDVGRASPLSSDSPVKTPIKVKVIEKDISVQAIACRSAPVSKTLSSSDTELLVLNGSDPVA 500

  Fly   546 DAAVRALQDGALSSSGSGGQP-SKSTLIIHSVQRNSSSPN-------AFKVELNRDGQIEVTDTA 602
            :.|:|.|.:   ||......| .|||:||..:.:.|.|.:       .:...::...|   .|..
Human   501 EVAIRQLSE---SSKLKLKSPRKKSTIIISGISKTSLSQDHDAALMQGYTASVDSTHQ---EDAP 559

  Fly   603 TELDQAVAQAFERAANEAQTEL-------EL---ELAKEEKSSQLGEPLIDSGNGTVNEESTAEF 657
            :..::|.|.|....|..||..|       ||   :|.||.:::.....::...:|....||:...
Human   560 SHPERAAASAPPEEAESAQASLAPKPQEDELDSWDLEKEPQAAAWSSQVLLDPDGDELSESSMSV 624

  Fly   658 GQPNAASSPNGSSYHNNYSLNGNGNSNGAGSGGYNSLPRNGGA---QQLAQQSGLLEGHDVVDDR 719
            .:|..|....|                        .:.|.|..   ::..||.          |.
Human   625 LEPGTAKKHKG------------------------GILRKGAKLFFRRRHQQK----------DP 655

  Fly   720 GRSKKRNFFGTLKK-RLSRSKTRTLSADQPNNNSHKSLSATNSNTTTATGFP 770
            |.|:..|....|:: ..||.|..||:     ...:|.|.:.:.|..|..|.|
Human   656 GMSQSHNDLVFLEQPEGSRRKGITLT-----RILNKKLLSRHRNKNTMNGAP 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10737	NP_001137711.1	C2_C21orf25-like	392..515	CDD:176060	28/144 (19%)
CG10737	NP_001137711.1	C1	879..930	CDD:237996
C2CD2	XP_011527824.1	C2_C21orf25-like	276..402	CDD:176060	29/128 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NK6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21119
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7506
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960