DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ena and VASP

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_003361.1	Gene:	VASP / 7408	HGNCID:	12652	Length:	380	Species:	Homo sapiens

Alignment Length:	702	Identity:	189/702 - (26%)
Similarity:	245/702 - (34%)	Gaps:	345/702 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 AEQSIIGARASVMVYDDNQKKWVPSGSS-SGLSKVQIYHHQQNNTFRVVGRKLQ-DHEVVINCSI 360
            :|..|..:||:||:|||..|:|:|:|:. ...|:|||||:...|:|||||||:| |.:|||||:|
Human     2 SETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAI 66

  Fly   361 LKGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTNGNGY 425
            ::|:||||||..||||||::.|:||||.|:.||..||..|..|||.|.|      |||
Human    67 VRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEG------GGP------- 118

  Fly   426 EEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAPPAPQP 490
                                                       |..|..|     |.|.|..|.|
Human   119 -------------------------------------------PPPPALP-----TWSVPNGPSP 135

  Fly   491 QQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQQQQFQQQQQQQQYQQMV 555
            ::.:||::.|                              |.|.:..:::
Human   136 EEVEQQKRQQ------------------------------PGPSEHIERR--------------- 155

  Fly   556 QAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGGMYMVGHGHLPSSASA 620
                            :||:
Human   156 ----------------VSNA--------------------------------------------- 159

  Fly   621 NSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQQQAENPYGQVPMPPPMNPSQQQQPGQ 685
                                          ||||.||    |..|      |||
Human   160 ------------------------------GGPPAPP----AGGP------PPP----------- 173

  Fly   686 VPLNRMSSQGGPGGPPAPAPPPPPPSFGGAAGGGPPPPAPPQMFNGAPPPPAMGGGPPPAPPAPP 750
                       ||.||.|.|||||         |.||...|...:||      |||||||||.|.
Human   174 -----------PGPPPPPGPPPPP---------GLPPSGVPAAAHGA------GGGPPPAPPLPA 212

  Fly   751 AMGGGPPPAPGGPGAPPPPPPPPGLGGAPKKEDPQADLMGSLASQLQQIKLKKNKVTTSAPENSG 815
            |.|      |||.||           |||           .||:.:...||:|   .:...|.||
Human   213 AQG------PGGGGA-----------GAP-----------GLAAAIAGAKLRK---VSKQEEASG 246

  Fly   816 SSTSSGGSGNYGTIGRSSNGMASMMDEMAKTLARRR--AQAEKKDP--------DPEAEVK---- 866
            ..|:.....     |||..|  .:|:||...|||||  .|..:|.|        :|||.|.
Human   247 GPTAPKAES-----GRSGGG--GLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSE 304

  Fly   867 --KRPWEK-SNTLPHKLSGGAGSGSAGSGHEGANGNSGGAGSNTTNSGGESPRPMRKRFGSASEE 928
              :||||| |.|||...|                      .|:.|.|..:...|      |:|:.
Human   305 SVRRPWEKNSTTLPRMKS----------------------SSSVTTSETQPCTP------SSSDY 341

  Fly   929 TILKVNGDGLSLALSNGDLDTLKAEIVREMRLEIQKVKNEIIDAIKSEFNRR 980
            :                ||..:|.|::.|::.|:||||.|||:|...|..:|
Human   342 S----------------DLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKR 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	61/108 (56%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929	15/33 (45%)
VASP	NP_003361.1	EVH1_Ena_VASP-like	5..113	CDD:269918	61/107 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..343		112/557 (20%)
		EVH2	225..377		59/205 (29%)
		EVH2 block A	225..245		6/22 (27%)
		KLKR	234..237		2/2 (100%)
		EVH2 block B	259..278		9/20 (45%)
		VASP_tetra	342..376	CDD:285929	15/49 (31%)
		EVH2 block C	343..377		15/33 (45%)
		2 X 15 AA tandem repeats of L-[EQ]-[KR]-[MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]-[KRV]- [KQ]-E	344..373		13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001160
OrthoInspector	1	1.000	-	-		otm40761
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830