DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ena and evla

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_005158849.1	Gene:	evla / 58003	ZFINID:	ZDB-GENE-000607-65	Length:	663	Species:	Danio rerio

Alignment Length:	754	Identity:	247/754 - (32%)
Similarity:	324/754 - (42%)	Gaps:	193/754 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 AEQSIIGARASVMVYDDNQKKWVP-SGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSIL 361
            :||||..||||||:|||..||||| .....|.|::.|||:..||:|||||.||||.:||||.||:
Zfish    27 SEQSICQARASVMIYDDTSKKWVPVKPGQQGFSRINIYHNTVNNSFRVVGVKLQDQQVVINYSIV 91

  Fly   362 KGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVL----SGRVANNPGGPPT-N 421
            |||||||||.|||||||::.||||||:|:.:|..|:.||:.||.||    :|..|:...||.| :
Zfish    92 KGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSTAMLFALNVLGSQDAGPGAHRQNGPVTDD 156

  Fly   422 GNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTP-----SAQTPTSQTNQNNIPQSPPTPQGHHRT 481
            |......|    |......:.|:..:.|..|:.     ||....|:|:.:::.|        :|.
Zfish   157 GEAQRRQM----MDQHQMQMERERRTSGSAVSTLQFKVSASASQSETSLHDLRQ--------YRA 209

  Fly   482 SSAPPAPQPQQQQQQQQAQQMGQPGSHYGP------TGNGPTSNGLPQQVNSQIPPAPQQQPQQQ 540
            ::.||:                  .:|..|      |...|...|....|:|         ||
Zfish   210 NTLPPS------------------YAHLNPAASSAHTATPPLQEGGYHMVDS---------PQ-- 245

  Fly   541 QFQQQQQQQQYQQMVQAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGG 605
              ::.||..|....:.:.::|.||...|        |...:.|.|..      |...|..|:: .
Zfish   246 --KKAQQLSQLSTSLASAFSPVQQGVVP--------PPRNIKQIPLS------PPTSQQDLKH-A 293

  Fly   606 MYMVGHGHLPSSASANSVVYASQQQMLPQAHPQAP--QAPTMPGPGYGGPPVPPPQQ----QAEN 664
            .:...|.:.|..|::..||.|.:|..||.|.|..|  ..|..|.......|:...||    |||.
Zfish   294 TWSSAHMYAPLPAASPPVVMAVKQPGLPVALPLPPLNNGPKAPSNTSHLDPIMHLQQSSNGQAEE 358

  Fly   665 --PYGQVPMPPPMNPSQQQQPGQVPLNRMSSQG--GPG---------GPPAPAPP--------PP 708
              || |.|...|::|....|....||..:..|.  |||         .||....|        .|
Zfish   359 CYPY-QSPSGGPLHPHYPIQESSCPLPPLIGQSVQGPGLHPQQLYQTTPPFETTPTSHTTPKTSP 422

  Fly   709 PPSF--GGAAGGGPP-PPAPPQMFNGAPP--PP---AMGGGPPPAPPAPPAMGGGPPPAPGGPGA 765
            .|.:  ..||..||| ||..|.|.:.|||  ||   :|.|  |||||.||   |.|||.|..||.
Zfish   423 SPVYQNAAAASTGPPVPPGHPSMLSAAPPVHPPTSASMVG--PPAPPPPP---GPPPPGPPPPGP 482

  Fly   766 PP----PPPPPPGL--GGAPKKEDPQADLMGSLASQLQQIKLKKNKVTTSAPENSGSSTSSGGSG 824
            ||    |||.||.|  ||.|......|.|.|:...::|:.:...:....|:...:.:|.||||||
Zfish   483 PPPVTGPPPTPPPLPAGGGPAPSGLAAALAGAKLRKVQRPEESSSSSNNSSNSKNDASRSSGGSG 547

  Fly   825 NYGTIGRSSNGMASMMDEMAKTLARRRAQAEKKDPDPEAEVK--------------KRPWEKSNT 875
                     .|...:|.||...|||||..:||.:.....|..              |:|||::|:
Zfish   548 ---------GGGEGLMQEMNALLARRRKASEKPEDSQNEESNGSPSSSRGQNSDPVKKPWERANS 603

  Fly   876 LPHKLSGGAGSGSAGSGHEGANGNSGGAGSNTTNSGGESPRPMRKRFGSASEETILKVNGDGLSL 940
                    |...||.|                          ..|..||.|:
Zfish   604 --------ADKSSAVS--------------------------RAKPLGSTSD------------- 621

  Fly   941 ALSNGDLDTLKAEIVREMRLEIQKVKNEIIDAIKSEFNR 979
             ..:.|.|.:|.||:.|:..|:||||.||||||:.|..|
Zfish   622 -AESFDFDRMKQEILEEVVRELQKVKEEIIDAIRRELLR 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	69/111 (62%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929	18/33 (55%)
evla	XP_005158849.1	EVH1_Ena_VASP-like	30..137	CDD:269918	67/106 (63%)
evla	XP_005158849.1	VASP_tetra	625..659	CDD:285929	18/33 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001160
OrthoInspector	1	1.000	-	-		otm24633
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.900