Protein Alignment ena and ENAH

DIOPT Version :9

• Sequence 1: NP_001137709.1
• Gene: ena / 37201
• FlyBaseID: FBgn0000578
• Length: 980
• Species: Drosophila melanogaster
• Sequence 2: XP_024304073.1
• Gene: ENAH / 55740
• HGNCID: 18271
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 925
• Identity: 262/925 - (28%)
• Similarity: 353/925 - (38%)
• Gaps: 325/925 - (35%)

  Fly   295 TIFAEQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCS 359
            |..:||||..|||:||||||..|||||:|.|:|.|:|.||||..||||||||||:|||:|||||:
Human   261 TTRSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCA 325

  Fly   360 ILKGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTNGNG 424
            |.|||||||||.|||||||::.||||||.|:.||..||.|||||||||:.
Human   326 IPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNS--------------- 375

  Fly   425 YEEDMGYRTMTSEDAAIL--------------RQNNSIGGHVT--PSAQTPTSQ----------- 462
             :|....:...::|:..|              |||:.:...|.  ||.:....|
Human   376 -QETAQSKVTATQDSTNLRCIFCVFYLGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQK 439

  Fly   463 --------------------------------------------------------------TNQ 465
                                                                          ..|
Human   440 ELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQ 504

  Fly   466 NNIPQSPPTPQGHHRTSSAPPAPQPQQQQQQQQAQQM---------------------------- 502
            ..:.:.....|...|........|.:::|:|.:.:|:
Human   505 ERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAPSSDSSLYNAPLPEYS 569

  Fly   503 -----GQPGSHYGPTGNGPTSNGLPQ-QVNSQIPP--APQQQPQQQQFQQQQQQQQYQQMVQAGY 559
                 ..|...|....:.|.|:..|. .|.:.:||  .|...|      .:....::...:.:.:
Human   570 SCQPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPP------LRHSATRFATSLGSAF 628

  Fly   560 APSQQYQQPHYVL------SNSNPNLTVHQYPTQQAQQQP---------PQAPQPPLQNGGMYMV 609
            .|    ..|||..      .||.|:..|:...:|....:|         |..|.||:      |:
Human   629 HP----VLPHYATVPRPLNKNSRPSSPVNTPSSQPPATKPCAWSTSNFSPLPPSPPI------MI 683

  Fly   610 GHGHLPSSASANSVVYASQQQMLP----QAHPQAPQAPTMP-----------------GPGYGGP 653
            ...  |..|:       ..:.:||    ...||.|.:||.|                 ||....|
Human   684 SSP--PGKAT-------GPRPVLPVCVSSPVPQMPPSPTAPNGLVDSVTYPVSPPPTSGPAAPPP 739

  Fly   654 PVPPPQQQAENPYGQVPMPPPMNP---SQQQQPG-------------QVPLNRM---SSQGGPG- 698
            |.|.|...:.:..|....|||..|   :...:|.             :.|||.:   ||...||
Human   740 PPPLPSLASLSHCGSQASPPPSTPIASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSASEPGL 804

  Fly   699 -----------------GPPAPAPPPP-PPSFGGAAGGGPPPPAPPQMFNGAPPPPAMGGGPPPA 745
                             ||.||.|||| ||....|:...||||.||      ||||....||||.
Human   805 QAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP------PPPPLPSTGPPPP 863

  Fly   746 PPAPPAMGGGPPPAPGGPGAPPPPPPPP----GLGGAPKKEDPQADLMGSLASQLQQIKLKK--N 804
            ||.||.....|||       |||||.||    |...|...||.:.  :..||:.:...||:|  .
Human   864 PPPPPLPNQVPPP-------PPPPPAPPLPASGFFLASMSEDNRP--LTGLAAAIAGAKLRKVSR 919

  Fly   805 KVTTSAPE-------NSGSSTSSGGSGNYGTIGRSSNGMASMMDEMAKTLARRRAQAEK------ 856
            ...||.|.       ||.||.:..|.||    |....|.:.:|:||:..|||||..|||
Human   920 MEDTSFPSGGNAIGVNSASSKTDTGRGN----GPLPLGGSGLMEEMSALLARRRRIAEKGSTIET 980

  Fly   857 -------KDPDP---------EAEVKKRPWEKSNTLPHKLSGGAGSGSAGSGHEGANGNSGGAGS 905
                   :|.:|         ..|..::|||::||:                    ||:     .
Human   981 EQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTM--------------------NGS-----K 1020

  Fly   906 NTTNSGGESPRPMRKRFGSASEETILKVNGDGLSLALSNG------DLDTLKAEIVREMRLEIQK 964
            :...|..:|||..:..|.:.|.:::.:.....||...:||      |.|.||.:|:.|||.|:.|
Human  1021 SPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTK 1085

  Fly   965 VKNEIIDAIKSEFNR 979
            :|.|:||||:.|.::
Human  1086 LKEELIDAIRQELSK 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	79/106 (75%)
		VASP_tetra	945..979	CDD:285929	18/39 (46%)
ENAH	XP_024304073.1	EVH1_Ena_VASP-like	267..374	CDD:269918	79/106 (75%)
		Atrophin-1	<614..849	CDD:331285	59/253 (23%)
		VASP_tetra	1067..1101	CDD:312347	17/34 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142463
Domainoid	1	1.000	164	1.000	Domainoid score	I3956
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3197
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001160
OrthoInspector	1	1.000	-	-		otm40761
orthoMCL	1	0.900	-	-		OOG6_106471
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3391
SonicParanoid	1	1.000	-	-		X5267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780