DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ena and enah

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	XP_009292985.1	Gene:	enah / 541394	ZFINID:	ZDB-GENE-010323-11	Length:	824	Species:	Danio rerio

Alignment Length:	879	Identity:	262/879 - (29%)
Similarity:	346/879 - (39%)	Gaps:	281/879 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 IFAEQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSI 360
            :..||||..|||:||||||..|||||:|.|:|.|:|.||||..||.|||||||:|||:|||||:|
Zfish    28 VHREQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAI 92

  Fly   361 LKGLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPP------ 419
            .|||||||||.|||||||::.||||||.|:.||..||.|||||||||:.:.|    |||
Zfish    93 PKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQDA----GPPLPRQTP 153

  Fly   420 --TNGNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQ---------TNQNNIPQSPP 473
              .||...||....|....|   :.||.......:....|....|         |.:....:...
Zfish   154 QVQNGPSPEELEVQRRQLQE---LQRQKEKEQERLDRERQERERQEREMLERERTERERQDRERQ 215

  Fly   474 TPQGHHRTSSAPPAPQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQ 538
            ..:...|........:.::..:::|.|::.:                 .::...::....:.:.:
Zfish   216 DRERQERERLERERTEQERLDRERQEQELLE-----------------RERQERELMERERAERE 263

  Fly   539 QQQFQQQQQQQQYQQMVQAG------------YAPSQQYQQPHY--VLSNSNPNLTVHQYPTQQA 589
            :|:.:||:|..:.|...:.|            |.|    ..|.|  ..|:|..:.:...||....
Zfish   264 KQEREQQEQLDREQMDWERGRRISNAAFESTLYTP----PPPEYNKTTSSSPVSPSTPSYPPPAP 324

  Fly   590 QQQPPQAPQPPLQN---------GGMYMVGHGHLPSSASANSVVYASQQQMLPQAHPQAPQAPTM 645
            .......|.|||::         |..:   |..||..|:            :|:..| ||..|..
Zfish   325 LPSTATPPTPPLRHSASRFATSLGSAF---HPVLPHYAT------------VPRRQP-APPTPPP 373

  Fly   646 PGPGYGGP------------PVPP-PQQQAENPYGQVPMPPPM------NPSQQQQPGQVPLNRM 691
            |.|....|            |:|| |.....:|.|:...|.||      :|..|:.|..:
Zfish   374 PAPAPPPPSKSVIWTANNFTPLPPSPPVMISSPPGKATGPRPMIAIPAPSPLSQKPPSPI----- 433

  Fly   692 SSQGGPGGPPA------------------PAPPPPPPSFG------------------------- 713
               ..|.|||.                  |.||||||.:.
Zfish   434 ---SAPNGPPTSLHFHTSSPVSGQPFSSPPTPPPPPPLYSPSPTLPHLAPHVSCPSPQPAVLPSP 495

  Fly   714 -----------------------------------------GAAGGGPPPPAPPQ-----MFNGA 732
                                                     |.....||||.||.     ...|.
Zfish   496 STAFPASAEHSVNSGLGDSCFSAPEPPTHPADFPSQPDSAHGVPTPPPPPPLPPSSTVTPTTAGP 560

  Fly   733 PPPPAMGGGPPPAPPAPPAM-------GGGPPPAPGG---PGAPPPPPPPP---GLGGAPKKEDP 784
            ||||   |.|||.||.||.:       ..||||.|.|   |.||||||.||   ||.......|.
Zfish   561 PPPP---GPPPPPPPLPPTLTPTGPPPPPGPPPPPSGQAPPPAPPPPPAPPLPSGLFTPSPTTDE 622

  Fly   785 QADLMGSLASQLQQIKLKKNKVTTS----APENSGSSTSSGGSGNYGTIGRSS-NGMASMMDEMA 844
            ...|.| ||:.|...|||  ||..|    ||. :||:.||||:....:.|... .|...:|:||:
Zfish   623 NKGLSG-LAAALAGAKLK--KVPRSDEPLAPA-AGSAVSSGGAKPEASRGNGPLPGGGGLMEEMS 683

  Fly   845 KTLARRRAQAEK-KDPDPE-------------------AEVKKRPWEKSNTLPHKLSGGAGSGSA 889
            ..|||||..||| ..|:||                   .::.::|||::||:       .||.|.
Zfish   684 ALLARRRRIAEKGSSPEPEQKADDFEATVTPKVSACSTPDMPRKPWERTNTM-------NGSKSP 741

  Fly   890 GSGHEGAN-GNSGGAGS--NTTNSGGESPRPMRKRFGSASEETILKVNGDGLSLALSNG------ 945
            ..|..... .|..|...  ::.|....:|.|.    ||.|                :||
Zfish   742 VIGRRDTPWRNQMGTDKYYDSLNRPRSTPTPT----GSIS----------------ANGVPTEAL 786

  Fly   946 DLDTLKAEIVREMRLEIQKVKNEIIDAIKSEFNR 979
            |.|.||.:|:.|||.|:.|:|.|:||||:.|..:
Zfish   787 DYDRLKQDILEEMRKELSKLKEELIDAIREELGK 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	78/106 (74%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929	18/39 (46%)
enah	XP_009292985.1	EVH1_Ena_VASP-like	33..140	CDD:269918	78/106 (74%)
enah	XP_009292985.1	VASP_tetra	787..820	CDD:285929	17/32 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575155
Domainoid	1	1.000	162	1.000	Domainoid score	I3963
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001160
OrthoInspector	1	1.000	-	-		otm24633
orthoMCL	1	0.900	-	-		OOG6_106471
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3391
SonicParanoid	1	1.000	-	-		X5267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730