DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ena and SPRED3

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001035987.1	Gene:	SPRED3 / 399473	HGNCID:	31041	Length:	410	Species:	Homo sapiens

Alignment Length:	512	Identity:	104/512 - (20%)
Similarity:	154/512 - (30%)	Gaps:	246/512 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 IIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQ--------QNNTFRVVGRKLQDHEVVINC 358
            ::..||.||..||:...|:|.| ..|||:|.:...:        :...:.:.|.:|:|.:..:.|
Human     1 MVRVRAVVMARDDSSGGWLPVG-GGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTLEC 64

  Fly   359 SILKGLKYNQATATFHQWR--DSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTN 421
            ::..||.||:....||.|.  |.||  ||.|.|..:|:.|.::::.||..| ||
Human    65 TLKPGLVYNKVNPIFHHWSLGDCKF--GLTFQSPAEADEFQKSLLAALAAL-GR----------- 115

  Fly   422 GNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAPP 486
                                        |.:|||:.:.:|..:|:               ::..|
Human   116 ----------------------------GSLTPSSSSSSSSPSQD---------------TAETP 137

  Fly   487 APQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQQQQFQQQQQQQQY 551
            .|                                |...|:|.
Human   138 CP--------------------------------LTSHVDSD----------------------- 147

  Fly   552 QQMVQAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGGMYMVGHGHLPS 616
                                 |:|:           .::|:.|                    ||
Human   148 ---------------------SSSS-----------HSRQETP--------------------PS 160

  Fly   617 SASANSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQQQAENPYGQVPMPPPMNPSQQQ 681
            :|:|..:...|                   ..|:|  |..|||::              ..|.|.
Human   161 AAAAPIITMES-------------------ASGFG--PTTPPQRR--------------RSSAQS 190

  Fly   682 QPGQVPLNRMSSQGGPGGPPAPAPPPPPPSFGGAAGGG--------PPPPAPPQMF--------N 730
            .|..:|...:           |.|..|....||...||        ..||||..:.        .
Human   191 YPPLLPFTGI-----------PEPSEPLAGAGGLGWGGRGYEDYRRSGPPAPLALSTCVVRFAKT 244

  Fly   731 GAPPPPAMGGGPPPAPPAPPAMGGGPPPAPGGPGAPPPPPPPPGLGGAPKKEDPQAD 787
            ||....|:  |||.|.|||  :....||||     |..|||.||...||.|..|:|:
Human   245 GALRGAAL--GPPAALPAP--LTEAAPPAP-----PARPPPGPGPSSAPAKASPEAE 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	35/115 (30%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929
SPRED3	NP_001035987.1	EVH1_SPRED-like	2..105	CDD:269978	33/105 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..210		32/260 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..288		16/36 (44%)
		Sprouty	296..400	CDD:398746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740