Protein Alignment ena and Spred3

DIOPT Version :10

• Sequence 1: NP_001137709.1
• Gene: ena / 37201
• FlyBaseID: FBgn0000578
• Length: 980
• Species: Drosophila melanogaster
• Sequence 2: XP_008757367.2
• Gene: Spred3 / 308478
• RGDID: 1311713
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 654
• Identity: 132/654 - (20%)
• Similarity: 187/654 - (28%)
• Gaps: 326/654 - (49%)

  Fly   179 SSSSSLIFSTLRKCVSPSNPSVNPN--QPSKTQPSKLGCSMSF-----SIRTTTATAATAAAANA 236
            |||.||         .||. :|.|.  .||...|.....|..|     |.|.....::.|.|:..
  Rat    10 SSSRSL---------GPSG-NVRPPCFYPSPKPPPPPHASSRFPLPPPSPRLPVPVSSAAGASQG 64

  Fly   237 ATATLSTQQQQQQAQQQHKQHLYSNIHHYLIRQQQQKQHYTLQRRHNSVKDKFIGGITTIFAEQS 301
            |.|.                           |:::::     .||..|...:.:.|       :.
  Rat    65 AGAN---------------------------RRRRRR-----PRRRRSEPGRSLPG-------RY 90

  Fly   302 IIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQ--------QNNTFRVVGRKLQDHEVVINC 358
            ::..||.||..||:...|:|.| ..|||:|.:...:        :...:.:.|.:|:|.:..:.|
  Rat    91 MVRVRAVVMARDDSSGGWLPVG-GGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTLEC 154

  Fly   359 SILKGLKYNQATATFHQWR--DSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTN 421
            ::..||.||:....||.|.  |.||  ||.|.|..:|:.|.:::..||..||
  Rat   155 TLRPGLVYNKVNPIFHHWSLGDCKF--GLTFQSPAEADEFQKSLQAALAALS------------- 204

  Fly   422 GNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAPP 486
                                       .|.:|||:.:.:|         ||      .|.::..|
  Rat   205 ---------------------------RGSLTPSSSSSSS---------SP------SRDTAETP 227

  Fly   487 APQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQQPQQQQFQQQQQQQQY 551
            .|                                |...|:|.
  Rat   228 CP--------------------------------LTSHVDSD----------------------- 237

  Fly   552 QQMVQAGYAPSQQYQQPHYVLSNSNPNLTVHQYPTQQAQQQPPQAPQPPLQNGGMYMVGHGHLPS 616
                                 |:|          :...|:.||.|..|              :.:
  Rat   238 ---------------------SSS----------SHSRQETPPTAVAP--------------IAT 257

  Fly   617 SASANSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQQQAENPYGQVPMPPPMNPSQQQ 681
            ..||.:.                             ||..|||::
  Rat   258 VESATAF-----------------------------PPATPPQRR-------------------- 273

  Fly   682 QPGQVPLNRMSSQGGPGGPPAPAPPPPPPSFGGAA----GG---------GPPPPAPPQMFN--- 730
                    |.|:|..|...|....|.|..|..||.    ||         ||||  ||...:
  Rat   274 --------RSSAQSYPPLLPFTGIPEPSESLAGAGSQGRGGRGYEDYRRSGPPP--PPLALSTCV 328

  Fly   731 ------GAPPPPAMGGGPP---PAP---PAPPAMGGGPPPAPGGPGAPPPPPPPPGLGGAPKKED 783
                  ||....|:  |||   |||   .||||:...|||.||         |.|    ||.|..
  Rat   329 VRFAKTGALRGAAL--GPPVSLPAPLTEAAPPALPARPPPGPG---------PTP----APAKAS 378

  Fly   784 PQAD 787
            |:|:
  Rat   379 PEAE 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	35/116 (30%)
		VASP_tetra	946..979	CDD:462599
Spred3	XP_008757367.2	EVH1_SPRED-like	90..205	CDD:269978	37/157 (24%)
		PRK12323	<247..>350	CDD:481241	35/177 (20%)
		Sprouty	386..490	CDD:461589