DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ena and Spred1

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_001040554.1	Gene:	Spred1 / 296072	RGDID:	1308735	Length:	444	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	87/364 - (23%)
Similarity:	132/364 - (36%)	Gaps:	85/364 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYH--HQQNN---TFRVVGRKLQDHEVVINC 358
            :.|....||.||..||:...|:|.| .||||.|.::.  .|:.|   .|.:.|.:|:|..||:.|
  Rat    11 DNSYARVRAVVMTRDDSSGGWLPLG-GSGLSIVTVFRVPQQEENGCADFYIRGERLRDKMVVLEC 74

  Fly   359 SILKGLKYNQATATFHQWR--DSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGP--P 419
            .:.|.|.||:.|.|||.|:  |.||  ||.|.|..||..|.|.:..|:|.:|      .|.|  .
  Rat    75 MLKKDLIYNKVTPTFHHWKIDDKKF--GLTFQSPADARAFDRGIRRAIEDIS------QGCPASK 131

  Fly   420 TNGNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSA 484
            |...|.::|:   ..|.||                   |..|....:...|........:|:|..
  Rat   132 TETEGGDDDL---QTTEED-------------------TSRSLVKDHFFQQETVVTCDPYRSSDI 174

  Fly   485 PPAPQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQ---QPQQQQFQQQQ 546
            .|.|......::...|                      .|| ||||...|.   |.:..::.|:|
  Rat   175 RPLPFEDLNARRVYLQ----------------------SQV-SQIPFCQQGLDIQSRSMEYVQRQ 216

  Fly   547 QQQQYQQMVQAGYAPSQQYQ-------------QPHYVL-----SNSNPNLTVHQYPTQQAQQQP 593
            ..::...:......|.:..:             .|..:|     ...:|::..:...........
  Rat   217 ISKECGSLKSQARVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDTDSSV 281

  Fly   594 PQAPQPPLQNGGMYMVGHGHLPSSASANSVVYASQQQML 632
            |.:.|...::...|..| .....|:..:|||:.:|...|
  Rat   282 PFSKQDSKKSDYFYHCG-DETKLSSLKDSVVFKTQPPSL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	46/113 (41%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929
Spred1	NP_001040554.1	EVH1_SPRED-like	13..125	CDD:269978	47/120 (39%)
Spred1	NP_001040554.1	Sprouty	333..428	CDD:282994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740