Protein Alignment ena and Enah

DIOPT Version :9

• Sequence 1: NP_001137709.1
• Gene: ena / 37201
• FlyBaseID: FBgn0000578
• Length: 980
• Species: Drosophila melanogaster
• Sequence 2: XP_030102994.1
• Gene: Enah / 13800
• MGIID: 108360
• Length: 860
• Species: Mus musculus
• Alignment Length: 913
• Identity: 263/913 - (28%)
• Similarity: 347/913 - (38%)
• Gaps: 320/913 - (35%)

  Fly   298 AEQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYHHQQNNTFRVVGRKLQDHEVVINCSILK 362
            :||||..|||:||||||..|||||:|.|:|.|:|.||||..||||||||||:|||:|||||:|.|
Mouse    33 SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPK 97

  Fly   363 GLKYNQATATFHQWRDSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPPTNGNGYEE 427
            ||||||||.|||||||::.||||||.|:.||..||.|||||||||               |..|.
Mouse    98 GLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVL---------------NSQEA 147

  Fly   428 DMGYRTMTSEDA-------------AILRQNNSIGGHVT--PSAQTPTSQTNQ------------ 465
            .....|.|.:..             .:.|||:.:...|.  ||.:....|..|
Mouse   148 AQSKVTATQDSTNLRCIFCVFYLGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELER 212

  Fly   466 -------------------------------------------------------------NNIP 469
                                                                         ..:.
Mouse   213 ERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQERERERLEQLE 277

  Fly   470 QSPPTPQGHHRTSSAPP--------APQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQ-QV 525
            :.....:...|.|:|.|        ||.|    :....|....|...|....:.|.|:..|. .|
Mouse   278 REQVEWERERRMSNAAPSSDSSLSSAPLP----EYSSCQPPSAPPPSYAKVISAPVSDATPDYAV 338

  Fly   526 NSQIPP--APQQQPQQQQFQQQQQQQQYQQMVQAGYAPSQQYQQPHYVL------SNSNPNLTVH 582
            .:.:||  .|...|      .:....::...:.:.:.|    ..|||..      .||.|:..|:
Mouse   339 VTALPPTSTPPTPP------LRHAATRFATSLGSAFHP----VLPHYATVPRPLNKNSRPSSPVN 393

  Fly   583 ------------QYPTQQAQQQPPQAP----QPPLQNGGMYMVGHGHLP---------------- 615
                        .:||......||..|    .||.:..|...|    ||
Mouse   394 TPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPV----LPVCVSSPVPQMPPSPTA 454

  Fly   616 SSASANSVVYASQQQMLPQAHPQAPQAPTMPGPGYGGPPVPPPQ-----------------QQAE 663
            .:.|.:||.|.....  |.:.|.||..|..|.|    ||.|||.                 .||.
Mouse   455 PNGSLDSVTYPVSPP--PTSGPAAPPPPPPPPP----PPPPPPPPLPPPPLPPLASLSHCGSQAS 513

  Fly   664 NPYG-------------------------QVPMPPPMNPSQQQQPG----QVPLNRMSSQGGPGG 699
            .|.|                         :.|:.|.:..|...:||    ..|....:.||...|
Mouse   514 PPPGTPLASTPSSKPSVLPSPSAAAPASAETPLNPELGDSSASEPGLQAASQPAESPTPQGLVLG 578

  Fly   700 PPAPAPPPPPPSFGGAAGGGPPPPAPPQMFNGAPPPPAMGGGPPPAPPAPPAMGGGPPPAPGGPG 764
            ||||.||||.||....|...||||.||      ||||....||||.||.       |||.|.  .
Mouse   579 PPAPPPPPPLPSGPAYASALPPPPGPP------PPPPLPSTGPPPPPPP-------PPPLPN--Q 628

  Fly   765 APPPPPPPP-------GLGGAPKKEDPQADLMGSLASQLQQIKLKKNKVTTSAPENSGSSTSSGG 822
            |||||||||       |:......||.:.  :..||:.:...||:|    .|..|:.    |..|
Mouse   629 APPPPPPPPAPPLPASGIFSGSTSEDNRP--LTGLAAAIAGAKLRK----VSRVEDG----SFPG 683

  Fly   823 SGNYGTIGRSSN-------------GMASMMDEMAKTLARRRAQAEK-------------KDPDP 861
            .||.|::..:|:             |.:.:|:||:..|||||..|||             :|.:|
Mouse   684 GGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRNEDAEP 748

  Fly   862 ---------EAEVKKRPWEKSNTLPHKLSGGAGSGSAGSGHEGANGNSGGAGSNTTNSGGESPRP 917
                     ..|..::|||::||:                    ||:     .:...|..:|||.
Mouse   749 ITAKAPSTSTPEPTRKPWERTNTM--------------------NGS-----KSPVISRRDSPRR 788

  Fly   918 MRKRFGSASEETILKVNGDGLSLALSNG------DLDTLKAEIVREMRLEIQKVKNEIIDAIKSE 976
            .:..|.:.:.:::.:......|...:||      |.|.||.:|:.|||.|:.|:|.|:||||:.|
Mouse   789 NQIVFDNRAYDSLHRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQE 853

  Fly   977 FNR 979
            .::
Mouse   854 LSK 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	79/106 (75%)
		VASP_tetra	945..979	CDD:285929	18/39 (46%)
Enah	XP_030102994.1	EVH1_Ena_VASP-like	36..143	CDD:269918	80/121 (66%)
		PHA03247	<356..576	CDD:223021	47/233 (20%)
		VASP_tetra	823..857	CDD:370114	17/34 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832311
Domainoid	1	1.000	164	1.000	Domainoid score	I3937
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3376
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001160
OrthoInspector	1	1.000	-	-		otm42835
orthoMCL	1	0.900	-	-		OOG6_106471
Panther	1	1.100	-	-	O	PTHR11202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3391
SonicParanoid	1	1.000	-	-		X5267
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780