DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ena and Spred1

DIOPT Version :9

Sequence 1:	NP_001137709.1	Gene:	ena / 37201	FlyBaseID:	FBgn0000578	Length:	980	Species:	Drosophila melanogaster
Sequence 2:	NP_277059.1	Gene:	Spred1 / 114715	MGIID:	2150016	Length:	444	Species:	Mus musculus

Alignment Length:	363	Identity:	89/363 - (24%)
Similarity:	140/363 - (38%)	Gaps:	83/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 EQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYH--HQQNN---TFRVVGRKLQDHEVVINC 358
            :.|....||.||..||:...|:|.| .||||.|.::.  ||:.|   .|.:.|.:|:|..||:.|
Mouse    11 DNSYARVRAVVMTRDDSSGGWLPLG-GSGLSSVTVFRVPHQEENGCADFFIRGERLRDKMVVLEC 74

  Fly   359 SILKGLKYNQATATFHQWR--DSKFVYGLNFSSQNDAENFARAMMHALEVLS-GRVANNPGGPPT 420
            .:.|.|.||:.|.|||.|:  |.||  ||.|.|..||..|.|.:..|:|.:| |..|:.     |
Mouse    75 MLKKDLIYNKVTPTFHHWKIDDKKF--GLTFQSPADARAFDRGIRRAIEDISLGCPASK-----T 132

  Fly   421 NGNGYEEDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTSSAP 485
            ...|.::|:   ..|.||.:    .:.:..|.          ..|..:..|.|     :|:|...
Mouse   133 EAEGGDDDL---QTTEEDTS----RSLVKDHF----------FQQETVVTSEP-----YRSSDIR 175

  Fly   486 PAPQPQQQQQQQQAQQMGQPGSHYGPTGNGPTSNGLPQQVNSQIPPAPQQ---QPQQQQFQQQQQ 547
            |.|......::...|                      .|| ||||.:.|.   |.:..::.|:|.
Mouse   176 PLPFEDLNARRVYLQ----------------------SQV-SQIPFSQQGLDIQSRSMEYVQRQI 217

  Fly   548 QQQYQQMVQAGYAPSQQYQ-------------QPHYVL-----SNSNPNLTVHQYPTQQAQQQPP 594
            .::...:......|.:..:             .|..:|     ...:|::..:...........|
Mouse   218 SKECGSLKSQTRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDTDSSVP 282

  Fly   595 QAPQPPLQNGGMYMVGHGHLPSSASANSVVYASQQQML 632
            .:.|...::..:|..| .....|:..:|||:.:|...|
Mouse   283 FSKQDSKKSDYLYHCG-DETKLSSLKDSVVFKTQPPSL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ena	NP_001137709.1	EVH1_Ena_VASP-like	301..408	CDD:269918	47/113 (42%)
ena	NP_001137709.1	VASP_tetra	945..979	CDD:285929
Spred1	NP_277059.1	EVH1_SPRED-like	13..125	CDD:269978	47/114 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..287		1/18 (6%)
		Required for interaction with TESK1. /evidence=ECO:0000269\|PubMed:17974561	333..444
		Sprouty	333..428	CDD:282994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740