DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15111 and ABHD12B

DIOPT Version :9

Sequence 1:	NP_725856.1	Gene:	CG15111 / 37200	FlyBaseID:	FBgn0034419	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001193602.1	Gene:	ABHD12B / 145447	HGNCID:	19837	Length:	362	Species:	Homo sapiens

Alignment Length:	358	Identity:	114/358 - (31%)
Similarity:	174/358 - (48%)	Gaps:	65/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VVLPLIFRYSVTFQRGILFLTFIKYPKGLDLTKPESVGLYATRNFYITVKDHDQDEDGVRVGVWH 111
            |.||||..        :::..|.|.|..:||.||| :.:..|.|||:.|      |.||.:|:||
Human    64 VFLPLIDM--------LIYFNFFKAPFLVDLKKPE-LKIPHTVNFYLRV------EPGVMLGIWH 113

  Fly   112 VLPSNAVRRFKRELRVEEEVAQDPDQQLDPAPGNERELKELSPAIRSEFPVVLPENEQLFYERLL 176
            .:||         .|.|:...:|                                  ..:||..|
Human   114 TVPS---------CRGEDAKGKD----------------------------------CCWYEAAL 135

  Fly   177 RMPGGTVVLYLHGNTASRGSGHRSEVYKLLRKLNYHVFSFDYRGYADSDPVPPTEEGVVRDAMMV 241
            | .|..:::||||:...|.:.||.::.|:|....:||.|.||||:.||.. .|||||:..||:.|
Human   136 R-DGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTG-KPTEEGLTTDAICV 198

  Fly   242 FEYI-ANTTSNPIVVWGHSLGTGVATHLCAKLASLRERAPRGVILESPFTNIRDEIRMHPFAKLY 305
            :|:. |.:...|:.:|||||||||||: .||:...:......::||:||||:......:|..|:|
Human   199 YEWTKARSGITPVCLWGHSLGTGVATN-AAKVLEEKGCPVDAIVLEAPFTNMWVASINYPLLKIY 262

  Fly   306 KNLPWFNFTISQPMYTNRLRFESDVHVLEFRQPIMIIHAEDDVVVPFNLGYRLYRIALDGRSRTS 370
            :|:|.|..|:...:..:::.|.:|.:|.....|::|:|.|||..||...|.:||.||.:. .|..
Human   263 RNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILHGEDDRTVPLEYGKKLYEIARNA-YRNK 326

  Fly   371 GPVEFHRFGASRKYGHKYLCRAPELPGLIQKFV 403
            ..|:...|...  :.|..||::|.|...::.|:
Human   327 ERVKMVIFPPG--FQHNLLCKSPTLLITVRDFL 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15111	NP_725856.1	Abhydrolase_5	183..381	CDD:289465	74/198 (37%)
ABHD12B	NP_001193602.1	Hydrolase_4	141..343	CDD:288960	75/206 (36%)
ABHD12B	NP_001193602.1	Abhydrolase_5	142..324	CDD:289465	71/184 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158517
Domainoid	1	1.000	133	1.000	Domainoid score	I5072
eggNOG	1	0.900	-	-		E1_COG1073
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3330
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45520
OrthoDB	1	1.010	-	-		D385100at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12277
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.870