DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15118 and ANKRD13A

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_005254037.1	Gene:	ANKRD13A / 88455	HGNCID:	21268	Length:	591	Species:	Homo sapiens

Alignment Length:	662	Identity:	258/662 - (38%)
Similarity:	377/662 - (56%)	Gaps:	98/662 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSVEEIKAEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKC 65
            |.|..:....||||..:|.|:..||:..:...:.|.:||||||.|.|||.|.:|...:.||..|.
Human     1 MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKA 65

  Fly    66 NATYE-YEGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEF 129
            :.|.| .:||:::.|||.|||.:::..:::.||.......:..||:|||.:|:|||||::|||||
Human    66 DVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEF 130

  Fly   130 TSWVPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKGAKETATMIEIDHDTN 194
            ||||||:||:||:|..:::|.||.:|:|.|||||:|.:|.||.||:||||....|.::|::||..
Human   131 TSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDK 195

  Fly   195 EVMVE--EMSSDIGDIV--AIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWRSEKSEM 255
            .|..|  ::|.::..:.  .:.|....|..||.:|||..:::...|:|||.|.|.||||::|:|:
Human   196 VVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEV 260

  Fly   256 INGYNCKVYGASNVEFVTKTRMDHLSEEQIKN-KTARTPLHSLLGIADEDYVSPADAAAALKDRT 319
            :|||..|||..:||..:||.|.:||:||:.|. |..|.||.||||..:..:      .|..:|.|
Human   261 VNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQF------GAQGQDLT 319

  Fly   320 PSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFTQEFDLHGRDVGGPK 384
                 .|.:.|       |:|                    :::||:|||.:||||..||:|.||
Human   320 -----TECATA-------NNP--------------------TAITPDEYFNEEFDLKDRDIGRPK 352

  Fly   385 NLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAGFPVKVEIPL 449
            .|:.:.|:|:|.||:.||.|:.|.|||:||:|||: ..|.|.::|||||.::.|.|||||:||||
Human   353 ELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMA-RTSAHFARLRDFIKLEFPPGFPVKIEIPL 416

  Fly   450 FHVLNACITFGNVFALTTPVDHVATLQEQDRVTCL-------VDDRCFDIPAHY--TNRGSDVRR 505
            ||||||.||||||...:|..:.|:...|..:....       ||...|:||..|  .:.|.:|..
Human   417 FHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHL 481

  Fly   506 QIPLDED-DMLQYAIEQSLVETSGACGVDARDDDKVDIWEVLRGQNVVGSDLLPED--------- 560
            |   ||| :::|:||:|||:|:|                   |.|.:.|    |..
Human   482 Q---DEDYEIMQFAIQQSLLESS-------------------RSQELSG----PASNGGISQTNT 520

  Fly   561 -DEQLQRVLQESLLGAHANLQSGSPASDEDDDGGFRYVDPDLAMAMRLSQQEQRKFELERQQEQE 624
             |.|.:|.:|||||.:...|   .|::..:..   |: |.||.:||.||.:|..::||..|:|:.
Human   521 YDAQYERAIQESLLTSTEGL---CPSALSETS---RF-DNDLQLAMELSAKELEEWELRLQEEEA 578

  Fly   625 MIEQALKLSLQE 636
            .::|.|:|||.:
Human   579 ELQQVLQLSLTD 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	34/84 (40%)
		ANK repeat	12..38	CDD:293786	8/25 (32%)
		Ank_2	13..94	CDD:289560	32/81 (40%)
		ANK repeat	40..70	CDD:293786	14/29 (48%)
		GPCR_chapero_1	155..497	CDD:288735	144/355 (41%)
		vWFA	<558..627	CDD:294047	24/78 (31%)
ANKRD13A	XP_005254037.1	Ank_2	13..96	CDD:403870	32/82 (39%)
		ANK repeat	40..71	CDD:293786	14/30 (47%)
		GPCR_chapero_1	156..470	CDD:403196	143/352 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147682
Domainoid	1	1.000	275	1.000	Domainoid score	I1761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1497
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52387
OrthoDB	1	1.010	-	-		D274804at33208
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	1	1.000	-	-		otm40428
orthoMCL	1	0.900	-	-		OOG6_102396
Panther	1	1.100	-	-	O	PTHR12447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7827
SonicParanoid	1	1.000	-	-		X742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.940