DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15118 and ankrd13c

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001039126.1	Gene:	ankrd13c / 733949	XenbaseID:	XB-GENE-5828071	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	140/474 - (29%)
Similarity:	233/474 - (49%)	Gaps:	96/474 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKCNATYEY-- 71
            |.:|:|..::..::.:|.:.|..:...:.|..|.|||.|||.|.|..|...|||.  ||..:.
Frog    80 AYFPVHECVFKGDIRRLSSLIRSHSIGQKDNHGNTPLHLAVMLGNKECAHLLLAH--NAPVKVKN 142

  Fly    72 -EGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEFTSWVPL 135
             :|||.:.||:..||..::||::.....|.........|:||:.|.:..|||:|:.|:|.|||||
Frog   143 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPL 207

  Fly   136 MSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKG-AKETATMIEID--------- 190
            :||:.|||..|:||:|.|:|:||||:.|.:...|||:.|:||.| |..:.:.:.:|
Frog   208 LSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKVYQRI 272

  Fly   191 -HDTNEVMVEE-----MSSDIGDIVAIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWR 249
             |:.:|:..||     |||||                .:|.:.|.:     |||.|.:.| |.:|
Frog   273 HHEESEMETEEEVDILMSSDI----------------YSATLSTKS-----ISFTRAQTG-WLFR 315

  Fly   250 SEKSEMINGYNCKVYGASNVEFVTKTRMDHLSEEQI-KNKTARTPLHSLLGIADEDYVSPADAAA 313
            .:|:|.:..:....:..:.:...::.|.:||:||.| :||.....|.....:.::::
Frog   316 EDKTERVGNFLADFHLVNGLILESRKRREHLTEEDILRNKAIMESLSKGGNLMEQNF-------- 372

  Fly   314 ALKDRTPSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFTQEFDL--H 376
                               |...|.|..|               .|.:::|.|||.:.|...  |
Frog   373 -------------------EPVRRQSLTP---------------PPPNTITWEEYISAENGKAPH 403

  Fly   377 -GRDVGGPKNLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAG 440
             ||::...:|..|    |:|.:.::::.|:.: |.:|.:|::::..  .|.:|||:|:.|:||.|
Frog   404 LGRELVCKENKKT----FKATIAMSQDFPLGI-ESLLNVLEVIAPF--KHFNKLREFVQMKLPPG 461

  Fly   441 FPVKVEIPLFHVLNACITF 459
            ||||::||:|..:.|.:||
Frog   462 FPVKLDIPVFPTITATVTF 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	29/86 (34%)
		ANK repeat	12..38	CDD:293786	4/25 (16%)
		Ank_2	13..94	CDD:289560	28/83 (34%)
		ANK repeat	40..70	CDD:293786	15/29 (52%)
		GPCR_chapero_1	155..497	CDD:288735	84/325 (26%)
		vWFA	<558..627	CDD:294047
ankrd13c	NP_001039126.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Ank_2	60..142	CDD:372319	21/63 (33%)
		ANK 1	79..110		5/29 (17%)
		ANK repeat	83..109	CDD:293786	4/25 (16%)
		ANK repeat	111..142	CDD:293786	15/32 (47%)
		ANK 2	111..140		15/30 (50%)
		Ank_4	112..165	CDD:372654	24/54 (44%)
		ANK 3	144..173		10/28 (36%)
		GPCR_chapero_1	227..500	CDD:371788	84/325 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425969at2759
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920