DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15118 and Ankrd13a

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001365826.1	Gene:	Ankrd13a / 68420	MGIID:	1915670	Length:	589	Species:	Mus musculus

Alignment Length:	669	Identity:	252/669 - (37%)
Similarity:	374/669 - (55%)	Gaps:	114/669 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSVEEIKAEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKC 65
            |.|..:..:.:|||..:|:|:.|||:..:...:.|.:||||||.|.|||.|.:|...:.||..|.
Mouse     1 MSSARDTSSRFPLHLLVWNNDYEQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKA 65

  Fly    66 NATYEY-EGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEF 129
            :.|.|. :||:::.|||.|||.:::..:::.||.......:..||:||..:|:|||||::|||||
Mouse    66 DVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMKWEF 130

  Fly   130 TSWVPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKGAKETATMIEIDHDTN 194
            ||||||:||:||:|..:::|.||.:|:|.|||||:|.:|.||.||:||||....|.::|::||..
Mouse   131 TSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGGDNWAELMEVNHDDR 195

  Fly   195 EVMVE--EMSSDIGDIV--AIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWRSEKSEM 255
            .|..|  ::|.::..:.  .:.|....|..||.:|||..:::...::|||.|.|.||||::|:|:
Mouse   196 VVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNVAFERTKSGFWGWRTDKAEV 260

  Fly   256 INGYNCKVYGASNVEFVTKTRMDHLSEEQIKN-KTARTPLHSLLGIADEDYVSPADAAAALKDRT 319
            :|||..|||..:||..:|:.|.:||:||:.|. |..|.||.||||..:..:
Mouse   261 VNGYEAKVYSVNNVSVITRIRTEHLTEEEKKRYKEDRNPLESLLGTVEHQF-------------- 311

  Fly   320 PSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFTQEFDLHGRDVGGPK 384
                                   |.|....:...:..:.| :::||:|||.::|||..||:|.||
Mouse   312 -----------------------GAQGQDLATECATVNNP-TAITPDEYFDEDFDLKDRDIGRPK 352

  Fly   385 NLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAGFPVKVEIPL 449
            .|:.:.|:|:|.||:.||.|:.|.|||:||:|||: ..|.|.::|||||.:..|.|||||:||||
Mouse   353 ELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMA-RTSAHFARLRDFIKLDFPPGFPVKIEIPL 416

  Fly   450 FHVLNACITFGNVFALT----------TPVDHVATLQEQDRVTCLVDDRCFDIPA--HYTNRGSD 502
            ||||||.||||||...:          ||.:.|:     :.....||...|:||.  |..:.|.:
Mouse   417 FHVLNARITFGNVNGCSTADESQGVEGTPAEAVS-----EATNFEVDQSVFEIPESYHIQDNGRN 476

  Fly   503 VRRQIPLDED-DMLQYAIEQSLVETSGACGVDARDDDKVDIWEVLRGQNVVGSDLLPED------ 560
            |..|   ||| :::|:||:|||:|:|                   |.|::.|    |..
Mouse   477 VHLQ---DEDYEIMQFAIQQSLLESS-------------------RSQDLSG----PASNGGVSH 515

  Fly   561 ----DEQLQRVLQESLLGAHANLQSGSPASDEDDDGGF----RYVDPDLAMAMRLSQQEQRKFEL 617
                :.|.:|.:|||||   .|::...|       ||.    |: |.||.:||.||.:|..:.||
Mouse   516 THSYEAQYERAIQESLL---TNMEGRCP-------GGLSESSRF-DSDLQLAMELSAKELAEREL 569

  Fly   618 ERQQEQEMIEQALKLSLQE 636
            ..|:|:..::|.|:|||.|
Mouse   570 RLQEEEAELQQVLQLSLTE 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	34/84 (40%)
		ANK repeat	12..38	CDD:293786	9/25 (36%)
		Ank_2	13..94	CDD:289560	33/81 (41%)
		ANK repeat	40..70	CDD:293786	14/29 (48%)
		GPCR_chapero_1	155..497	CDD:288735	137/358 (38%)
		vWFA	<558..627	CDD:294047	25/82 (30%)
Ankrd13a	NP_001365826.1	ANK repeat	12..38	CDD:293786	9/25 (36%)
		Ank_2	13..96	CDD:403870	33/82 (40%)
		ANK repeat	40..71	CDD:293786	14/30 (47%)
		ANK 1	40..69		13/28 (46%)
		ANK 2	73..102		10/28 (36%)
		GPCR_chapero_1	156..469	CDD:403196	136/356 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837764
Domainoid	1	1.000	273	1.000	Domainoid score	I1778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1457
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52387
OrthoDB	1	1.010	-	-		D425969at2759
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	1	1.000	-	-		otm42504
orthoMCL	1	0.900	-	-		OOG6_102396
Panther	1	1.100	-	-	O	PTHR12447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7827
SonicParanoid	1	1.000	-	-		X742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.940