DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15118 and ankrd13a

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001119859.1	Gene:	ankrd13a / 556837	ZFINID:	ZDB-GENE-030131-1833	Length:	623	Species:	Danio rerio

Alignment Length:	685	Identity:	253/685 - (36%)
Similarity:	376/685 - (54%)	Gaps:	121/685 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVEEIKAEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLL-----A 62
            |||:....:|||..:|.|:..:|:..|..::.|::||||||||.|||.|.:|..|:.||     .
Zfish     8 SVEDFSLRFPLHVLVWENDYRKLETEIQTSNIEEVDPRGRTPLHLAVSLGHLESVRVLLRHGADV 72

  Fly    63 AKCNATYEYEGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKW 127
            ||.|.    :.|:::||||.|||.:::..:::.||..:....:..||:||..:.::||||:||||
Zfish    73 AKENG----KNWTVLQEAVSTGDPEMVQLVLQRRDYLKASTALGGVPELLCKIRESPDFYMEMKW 133

  Fly   128 EFTSWVPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKGAKETATMIEIDHD 192
            |||||:||:||:||||..:::|.||.:|:|||||||:|.||.||.|||||:|......::|::|:
Zfish   134 EFTSWIPLVSRVCPSDVCRIWKSGACLRVDTTLLGFENMTWIRGRRSYIFRGEDNCTELMEVNHE 198

  Fly   193 TNEVMVE--EMSSDIGDIV--AIPPALGTVRARLNAPVITNNIEMDKISFERN------------ 241
            ...|..|  ::|.::.|:.  ::.||...|..||...::...::...|:||||
Zfish   199 DEVVDTERFDLSREMEDVTLDSMQPAEQEVAKRLTTSIVNTYLDTKDIAFERNAIKTFTRSILRA 263

  Fly   242 KCGIWGWRSEKSEMINGYNCKVYGASNVEFVTKTRMDHLS-EEQIKNKTARTPLHSLLGIADEDY 305
            |.|||||||:::|::|||..||:..:||..|.:||.:||: ||:.:.|:.|..|.||||..::..
Zfish   264 KSGIWGWRSDRTEVVNGYEAKVFSVNNVNVVIRTRTEHLTDEEKARIKSERNVLESLLGTVEQQI 328

  Fly   306 VSPADAAAALKDRTPSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFT 370
            .:..|..           :|.|                            |:|..:::||||||.
Zfish   329 GAQGDMT-----------MEFA----------------------------TATNPTAITPEEYFN 354

  Fly   371 QEFDLHGRDVGGPKNLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITM 435
            ..|||.|||:|.|..|:.:.|:|:..||::||||:.|.|||.||:|||: ..|.|.::|:|||.:
Zfish   355 PNFDLQGRDIGRPIELTIRTQKFKGTLWMSEEHPLSLVEQVTPIIDLMA-RTSTHFARLKDFINL 418

  Fly   436 QLPAGFPVKVEIPLFHVLNACITFGNVFALTT--PVD--HVATLQEQDRVTC------------- 483
            :.|.|||||:||||||||||.||||:|...:|  |:|  ..|:.......||
Zfish   419 RFPPGFPVKIEIPLFHVLNARITFGSVNKCSTDEPLDTKTPASTPTPTEETCDNQAAAPAGPAPL 483

  Fly   484 -LVDDRCFDIPAHYTNRG----SDVRRQIPLDED-DMLQYAIEQSLVETSGACGVDARDDDKVDI 542
             .|....|..||||.:||    ::.|:..|::.| ::|||||.|||:::|
Zfish   484 FQVSPSVFLAPAHYHHRGGYRHANPRQYNPVNHDEELLQYAIHQSLLDSS--------------- 533

  Fly   543 WEVLRGQNVVGSDLLPEDDEQLQRVLQESLL------GAHANLQSGSPASDEDDDGGFRYVDPDL 601
              ||..|     |...:.|.|..:.:...|.      |...:|...:|:|    .|.....|.||
Zfish   534 --VLNSQ-----DTWSDSDGQATQSMTNRLSDGSGSEGVLVDLSDTTPSS----SGSASSPDTDL 587

  Fly   602 AMAMRLSQQEQRKFELERQQEQEMIEQALKLSLQE 636
            .:||.||.:.|.:.|..|::|:|.:|:.|:|||.|
Zfish   588 RLAMELSARAQEEEEKRRKEEEEELERILQLSLTE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	35/88 (40%)
		ANK repeat	12..38	CDD:293786	8/25 (32%)
		Ank_2	13..94	CDD:289560	34/85 (40%)
		ANK repeat	40..70	CDD:293786	17/34 (50%)
		GPCR_chapero_1	155..497	CDD:288735	140/376 (37%)
		vWFA	<558..627	CDD:294047	20/74 (27%)
ankrd13a	NP_001119859.1	ANK	17..115	CDD:238125	37/101 (37%)
		ANK repeat	45..76	CDD:293786	16/30 (53%)
		Ank_4	46..99	CDD:290365	24/56 (43%)
		GPCR_chapero_1	161..498	CDD:288735	140/376 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581510
Domainoid	1	1.000	277	1.000	Domainoid score	I1690
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1437
OMA	1	1.010	-	-		QHG52387
OrthoDB	1	1.010	-	-		D274804at33208
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	1	1.000	-	-		otm25302
orthoMCL	1	0.900	-	-		OOG6_102396
Panther	1	1.100	-	-	O	PTHR12447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7827
SonicParanoid	1	1.000	-	-		X742
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.940