DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15118 and CG5742

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001261069.1	Gene:	CG5742 / 37072	FlyBaseID:	FBgn0034304	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	153/546 - (28%)
Similarity:	269/546 - (49%)	Gaps:	90/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EYPLHWHIWHNELEQLQAAI----DQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKCNATYE 70
            ::|:|..::.::::.||..:    .|::..:.|..|.|||.|||.|.....|:.|||.  ||..:
  Fly    84 DFPMHRSVFEDDIKSLQRRLLLSTAQDEVGRKDKHGNTPLHLAVMLGRKHAVRLLLAQ--NAPVK 146

  Fly    71 Y---EGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEFTSW 132
            .   ||||.:.||:..||...:|.::.:..||......:...||:..|....|||:|.||:|.||
  Fly   147 IKNNEGWSPLSEAISYGDRQTITQVLRMLKLQSREHMESRREKLVNALRQMQDFYMEFKWDFQSW 211

  Fly   133 VPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKG---AKETATMIEIDHDT- 193
            :||:||:.|||..::||.||::|:||||:.|::..|:||:.|::|:|   |:|:..:::.:.:.
  Fly   212 LPLVSRILPSDICRLYKSGASIRLDTTLVDFNDMRWERGDISFLFRGEAPARESLVLLDNEQECF 276

  Fly   194 NEVMVEEMSSDIGDIVAIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWRSEKSEMING 258
            ..:..||  ||:.|.|.:         .::..::...:....|.|.|.:.| |.:|:.:.|:|.|
  Fly   277 QRLRYEE--SDMEDEVDV---------LMSTDILATQMSTKTIQFARAQRG-WIFRANRKELIGG 329

  Fly   259 -YNCKVYGASNVEFVTKTRMDHLSEEQIKNKTARTPLHSLLGIADEDYVSPADAAAALKDRTPSP 322
             |.|::|....:....:.|.:|||.|.::..  |..:.::...|.:...:...:..:....||..
  Fly   330 QYQCEIYTIQGLILKQRKRREHLSHEDLQKN--RAIVETITKGASQQPDTRRSSLGSQHTATPPE 392

  Fly   323 RLEEASNAGVENGGRNSP-APGNQSNGSS-----AGASGTSTPKSSVTPEEYFTQEFDLHGRDVG 381
                          .|:| ||    ||.|     ..:|..:.|..:||..:|...|       ||
  Fly   393 --------------TNTPTAP----NGISLPELPRRSSLQAPPPPTVTWRQYLDAE-------VG 432

  Fly   382 G-PKNLSTKVQR-----FRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAG 440
            . |:...|.|.:     .||.:.::::.|:.: :.:|.:|::::.:  .|::|||:|:|::||.|
  Fly   433 KCPQLGRTPVHKQSNKTLRATVAMSKDFPLSV-DMLLDVLEVVAPL--KHINKLREFVTLKLPTG 494

  Fly   441 FPVKVEIPLFHVLNACITFGNVFALTTPVDHVATLQEQDRVTCLVDDRCFDIPAHYTNRGSDVRR 505
            ||||:|||:.|.:.|.:||             ...:.:|.:..    :.|::|:||   ..||||
  Fly   495 FPVKIEIPVLHTVTAKVTF-------------QKFEFRDNIPA----KMFEVPSHY---WEDVRR 539

  Fly   506 QIPLDEDDMLQYAIEQSLVETSGACG 531
            ...| ..|  ..|..::...|.|..|
  Fly   540 FQDLXPGD--GEAAPKAKAATGGPTG 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	29/90 (32%)
		ANK repeat	12..38	CDD:293786	5/29 (17%)
		Ank_2	13..94	CDD:289560	28/87 (32%)
		ANK repeat	40..70	CDD:293786	14/29 (48%)
		GPCR_chapero_1	155..497	CDD:288735	88/358 (25%)
		vWFA	<558..627	CDD:294047
CG5742	NP_001261069.1	ANK	86..>175	CDD:238125	29/90 (32%)
		ANK repeat	86..116	CDD:293786	5/29 (17%)
		Ank_5	104..156	CDD:290568	20/53 (38%)
		ANK repeat	118..149	CDD:293786	14/32 (44%)
		GPCR_chapero_1	234..534	CDD:288735	89/361 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449866
Domainoid	1	1.000	44	1.000	Domainoid score	I4699
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425969at2759
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	1	1.000	-	-		mtm1007
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950