DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15118 and Ankrd13a

DIOPT Version :9

Sequence 1:	NP_611396.1	Gene:	CG15118 / 37199	FlyBaseID:	FBgn0034418	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_006249523.3	Gene:	Ankrd13a / 360823	RGDID:	1308577	Length:	701	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	251/661 - (37%)
Similarity:	369/661 - (55%)	Gaps:	97/661 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSVEEIKAEYPLHWHIWHNELEQLQAAIDQNDKEKIDPRGRTPLMLAVRLANLPCVKCLLAAKC 65
            |.|..:..:.:|||..:|:|:..||:..:...:.|.:||||||.|.|||.|.:|...:.||..|.
  Rat   112 MSSARDTSSRFPLHLLVWNNDYRQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKA 176

  Fly    66 NATYEY-EGWSIVQEAVCTGDVDILTAIIEVRDLQRHVQRVTHVPKLLQHLLDAPDFYIEMKWEF 129
            :.|.|. :||:::.|||.|||.:::..:::.||.......:..||:||..:|:|||||::|||||
  Rat   177 DVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMKWEF 241

  Fly   130 TSWVPLMSRLCPSDTYKVYKRGANVRIDTTLLGFDNNTWQRGNRSYIFKGAKETATMIEIDHDTN 194
            ||||||:||:||:|..:::|.||.:|:|.|||||:|.:|.||.||.||||....|.::|::||..
  Rat   242 TSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSLIFKGGDNWAELMEVNHDDR 306

  Fly   195 EVMVE--EMSSDIGDIV--AIPPALGTVRARLNAPVITNNIEMDKISFERNKCGIWGWRSEKSEM 255
            .|..|  ::|.::..:.  .:.|....|..||.:|||..:::...::|||.|.|.||||::|:|:
  Rat   307 VVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNVAFERTKSGFWGWRTDKAEV 371

  Fly   256 INGYNCKVYGASNVEFVTKTRMDHLSEEQIKN-KTARTPLHSLLGIADEDYVSPADAAAALKDRT 319
            :|||..|||..:||..:||.|.:||:||:.|. |..|.||.||||..:..:
  Rat   372 VNGYEAKVYSVNNVSVITKIRTEHLTEEEKKRYKEDRNPLESLLGTVEHQF-------------- 422

  Fly   320 PSPRLEEASNAGVENGGRNSPAPGNQSNGSSAGASGTSTPKSSVTPEEYFTQEFDLHGRDVGGPK 384
                                   |.|....:...:..:.| :::||:|||.::|||..||:|.||
  Rat   423 -----------------------GAQGQDLTTECATVNNP-TAITPDEYFDEDFDLKDRDIGRPK 463

  Fly   385 NLSTKVQRFRANLWLAEEHPIRLQEQVLPILDLMSTMASPHVSKLRDFITMQLPAGFPVKVEIPL 449
            .|:.:.|:|:|.||:.||.|:.|.|||:||:|||: ..|.|.::|||||.:..|.|||||:||||
  Rat   464 ELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMA-RTSAHFARLRDFIKLDFPPGFPVKIEIPL 527

  Fly   450 FHVLNACITFGNVFALTTPVDH------VATLQEQDRVTCLVDDRCFDIPA--HYTNRGSDVRRQ 506
            ||||||.||||||...:|..:.      .|.....|.....||...|:||.  |..:.|.:|..|
  Rat   528 FHVLNARITFGNVNGCSTAEERQSVEGTQAECAASDATNFEVDQSVFEIPESYHVQDNGRNVHLQ 592

  Fly   507 IPLDED-DMLQYAIEQSLVETSGACGVDARDDDKVDIWEVLRGQNVVGSDLLPED---------- 560
               ||| :::|:||:|||:|:|                   |.|::.|    |..
  Rat   593 ---DEDYEIMQFAIQQSLLESS-------------------RSQDLSG----PASNGGVSHAHSY 631

  Fly   561 DEQLQRVLQESLLGAHANLQSGSPASDEDDDGGFRYVDPDLAMAMRLSQQEQRKFELERQQEQEM 625
            :.|.:|.:|||||   .|::...|....|..   |: |.||.:||.||.:|..:.||..|:|:..
  Rat   632 EAQYERAIQESLL---TNMEGRCPGGLSDSS---RF-DSDLRLAMELSAKELAEQELRLQEEEAE 689

  Fly   626 IEQALKLSLQE 636
            ::|.|:|||.|
  Rat   690 LQQVLQLSLTE 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15118	NP_611396.1	ANK	10..>94	CDD:238125	33/84 (39%)
		ANK repeat	12..38	CDD:293786	8/25 (32%)
		Ank_2	13..94	CDD:289560	32/81 (40%)
		ANK repeat	40..70	CDD:293786	14/29 (48%)
		GPCR_chapero_1	155..497	CDD:288735	138/354 (39%)
		vWFA	<558..627	CDD:294047	24/78 (31%)
Ankrd13a	XP_006249523.3	Ank_2	124..207	CDD:403870	32/82 (39%)
		ANK repeat	151..182	CDD:293786	14/30 (47%)
		GPCR_chapero_1	267..581	CDD:403196	137/352 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341508
Domainoid	1	1.000	275	1.000	Domainoid score	I1684
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1412
OMA	1	1.010	-	-		QHG52387
OrthoDB	1	1.010	-	-		D274804at33208
OrthoFinder	1	1.000	-	-		FOG0000585
OrthoInspector	1	1.000	-	-		otm44568
orthoMCL	1	0.900	-	-		OOG6_102396
Panther	1	1.100	-	-	O	PTHR12447
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X742
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910