DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment botv and Extl2

DIOPT Version :9

Sequence 1:	NP_523790.1	Gene:	botv / 37198	FlyBaseID:	FBgn0027535	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001156986.1	Gene:	Extl2 / 58193	MGIID:	1889574	Length:	330	Species:	Mus musculus

Alignment Length:	269	Identity:	88/269 - (32%)
Similarity:	132/269 - (49%)	Gaps:	59/269 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   712 EQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNS--PKPPLDDLRWPDIGV-PVAVLRAPR 773
            :.||::|.||.|..:|:..|.....:|.||||:||||:  .|.| ::| |..:|. |:.|:..|:
Mouse    65 DSFTLIMQTYNRTDLLLRLLNHYQAVPSLHKVIVVWNNVGEKGP-EEL-WNSLGPHPIPVIFKPQ 127

  Fly   774 --NSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYH--------- 827
              |.:.||...|..:||.|||.||||..:...:::|.|.:|::..|:::||..|.|
Mouse   128 TANKMRNRLQVFPEVETNAVLMVDDDTLISAQDLVFAFSIWQQFPDQIIGFVPRKHVSTSSGIYS 192

  Fly   828 --AWDLGNP---NGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDI 887
              .::|..|   ||.         :.||||.||:|.:..||.|:... |.|:...:||..||:||
Mouse   193 YGGFELQTPGPGNGD---------QYSMVLIGASFFNSKYLELFQKQ-PAAVHALIDETQNCDDI 247

  Fly   888 AMNFLVSHITRKP------PVKVTSRWTFRCPGCPVSLSEDDT----------HFQERHKCINFF 936
            ||||||:..|.||      |:.:            |:|.::..          ||.:|..|||..
Mouse   248 AMNFLVTRHTGKPSGIFVKPINM------------VNLEKETNGYSGMWHRAEHFLQRSYCINKL 300

  Fly   937 SRVFGYTPL 945
            ..::...||
Mouse   301 VNIYDGMPL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	TBPIP	<107..185	CDD:284512
		Exostosin	224..551	CDD:281069
		Glyco_transf_64	714..949	CDD:286358	88/267 (33%)
Extl2	NP_001156986.1	Glyco_transf_64	67..313	CDD:286358	88/267 (33%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:12562774	130..135		1/4 (25%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:12562774	151..153		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:12562774	242..246		2/3 (67%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:12562774	280..293		2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11062
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020