Protein Alignment botv and ext1b

DIOPT Version :9

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001012369.2
• Gene: ext1b / 497280
• ZFINID: ZDB-GENE-050211-4
• Length: 741
• Species: Danio rerio
• Alignment Length: 813
• Identity: 225/813 - (27%)
• Similarity: 358/813 - (44%)
• Gaps: 209/813 - (25%)

  Fly   197 PRKSNPITGGM--AASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTL 259
            ||:...:...:  ...|.|.:||:.|.|. .:||.||:|.      |:||..|....:..| .|:
Zfish    77 PRQKRDVNSSVYKGKRCRMQSCFDFSLCQ-RNGFKVYVYP------QQKGEKISESYQNIL-STI 133

  Fly   260 GYNAHIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLP 324
            ..:.....||..||::       :|..|.|..::.:.|...:.:              .|:.||.
Zfish   134 EGSRFYTSDPGQACVF-------VLSLDTLDRDQLSPQYVHNLK--------------TKVQSLA 177

  Fly   325 YWGGDGRNHVLLNLARRDLTSHRTNPLYRQ----NTMRAIVVQSAFEREQFRPGYDLIVP----- 380
            .| .:||||::.||      ...|.|.|.:    :..:|::.:::...|.|||.:|:.:|
Zfish   178 LW-NNGRNHLIFNL------YSGTWPDYTEDLGFDIGQAMLAKASISTENFRPNFDISIPLFSKE 235

  Fly   381 -PILGPPGGDVWQECAEMVPARRKYLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVL 444
             |   ..|||........:|..|||:|.::|:........:..:|....|.|        :..||
Zfish   236 HP---RTGGDRGYLKYNTIPPFRKYMLVFKGKRYLTGIGSDTRNALYHVHNA--------EDVVL 289

  Fly   445 QFQCVPATEQQEGDSLPDW-----TLCGSDSSR------RQLLKDSTFSLILPPLNGRVSSTLML 498
            ...|      :.|   .||     ..|..|::.      |::|.:|||.|:  |...|:.|
Zfish   290 LTTC------KHG---KDWQKHKDARCDKDNAEYDKYDYREMLHNSTFCLV--PRGRRLGS---- 339

  Fly   499 ARIYEALRSGAVPVILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQG 563
            .|..|||::..|||:| ::...||::|.:||...|::..:..:.::...:|::....:|.||:|.
Zfish   340 FRFLEALQAACVPVML-SNGWELPFSEVIDWNTAAVIGDERLLLQIPSTVRSIHQDKILALRQQT 403

  Fly   564 RLIWERYLSSVQATVDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEES- 627
            :.:||.|.|||:..|.|.:..::||          |:.||..:|.   :.:..|.||.:.|:.|
Zfish   404 QFLWEAYFSSVEKIVLTTLEIIQDR----------VLQQSSRSSV---MWNSHPGGLFSLPQYSS 455

  Fly   628 -LGPIEPPYPSPAFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTGFRPIG 691
             ||..                             ||: |.:|
Zfish   456 YLGDF-----------------------------PFF-YAKL----------------------- 467

  Fly   692 KGLGGAGKEFGESLGGNYPREQFTIVM-----LTYEREQV--LMDSLGRLYGLPYLHKVVVVWNS 749
                           |..|..:||.|:     |..:.:.:  |:.|:.|   ..|..:::|:||.
Zfish   468 ---------------GIKPSPKFTAVIHAVTPLVSQSQPILKLIVSVAR---SQYCAQIIVLWNC 514

  Fly   750 PKPPLDDLRWPDIGVPVAVLRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWRE 814
            .||.....|||...||:.|:......:::||.|::.:.::||||:|:|..|...|:.|.|.||:.
Zfish   515 DKPLPAKQRWPATAVPIIVIEGENKVMSSRFQPYESLISDAVLSLDEDTVLSTTEVDFAFTVWQS 579

  Fly   815 HRDRVVGFPGRYHAWDLGNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVD 879
            ..:|:||:|.|.|.||  |...:|.|.|.::.:.||||||||..|:||.:|||:.||.:::..||
Zfish   580 FPERIVGYPARSHFWD--NNKERWGYTSKWTNDYSMVLTGAAIYHRYYHFLYTHFLPSSLKSMVD 642

  Fly   880 EYMNCEDIAMNFLVSHITRKPPVKVT----------------SRWTFRCPGCPVSLSEDDTHFQE 928
            :..|||||.||||||.:|:.||||||                |||.            |..||.:
Zfish   643 QLANCEDILMNFLVSAVTKLPPVKVTQKKQYKETMMGQSSRASRWA------------DPDHFAQ 695

  Fly   929 RHKCINFFSRVFGYTPLLNTQYRADSILFKTRI 961
            |..|:|.|:..||..||:::|.|.|.:|||.::
Zfish   696 RQTCMNKFASWFGGMPLVHSQMRLDPVLFKDQV 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	TBPIP	<107..185	CDD:284512
		Exostosin	224..551	CDD:281069	84/347 (24%)
		Glyco_transf_64	714..949	CDD:286358	96/257 (37%)
ext1b	NP_001012369.2	Exostosin	105..391	CDD:281069	84/348 (24%)
		Glyco_transf_64	475..716	CDD:286358	96/257 (37%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89	539..544		0/4 (0%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89	560..562		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89	645..649		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89	683..696		6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920