Protein Alignment botv and EXTL1

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_004446.2
• Gene: EXTL1 / 2134
• HGNCID: 3515
• Length: 676
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 193/807 - (23%)
• Similarity: 317/807 - (39%)
• Gaps: 230/807 - (28%)

  Fly   193 PNTLPRKS-NPITGGMAASCEMHNCFNHSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLK 256
            |..||..: :|.......||...:||:.|:|. ..|..|::            |...|.:..|.:
Human    61 PGELPEDAVSPPQAPHGGSCNWESCFDTSKCR-GDGLKVFV------------YPAVGTISETHR 112

  Fly   257 QTLGY---NAHIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDME 318
            :.|..   :......|..||:.|:|                          |......:|.
Human   113 RILASIEGSRFYTFSPAGACLLLLL--------------------------SLDAQTGECS---- 147

  Fly   319 KLYSLPYWGGDGRNHVLLNLARRDLTSHRTNPLYRQNTM---RAIVVQSAFEREQFRPGYDLIVP 380
               |:|.....||||::|          |.:|.....|.   :|:|.:::...:.||||:|:.:|
Human   148 ---SMPLQWNRGRNHLVL----------RLHPAPCPRTFQLGQAMVAEASPTVDSFRPGFDVALP 199

  Fly   381 ------PILGPPGGDVWQECAEMVPARRKYLLTYQGE-----LRPKQSSLNPLDAFILEHLADMA 434
                  |:.|...|.:.|..    |.....||..:.|     .....||..|.|....:   |..
Human   200 FLPEAHPLRGGAPGQLRQHS----PQPGVALLALEEERGGWRTADTGSSACPWDGRCEQ---DPG 257

  Fly   435 KGATQDQFVLQFQCVPATEQQEGDSLPDWTLCGSDSSRRQLLKDSTFSLILPPLNGRVSSTLMLA 499
            .|.||.|                ::||:.|.|.....|.:                      ..:
Human   258 PGQTQRQ----------------ETLPNATFCLISGHRPE----------------------AAS 284

  Fly   500 RIYEALRSGAVPVILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGR 564
            |..:||::|.:||:| :....||::|.:||.:.|::..:....::...|:.:..|.:|.||:|.:
Human   285 RFLQALQAGCIPVLL-SPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEMSPARVLALRQQTQ 348

  Fly   565 LIWERYLSSVQATVDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIP--LKSDPPVGL------D 621
            .:|:.|.|||:..:.|.:..::||               :|.::..|  |.:.||..|      .
Human   349 FLWDAYFSSVEKVIHTTLEVIQDR---------------IFGTSAHPSLLWNSPPGALLALSTFS 398

  Fly   622 TEPEESLGPIEPPYPSPAFRRNYTILRMQAKEAWNDWLDPFYLYPQLPFDPALPSEAKFMGSHTG 686
            |.|::.                                 |||...|                  |
Human   399 TSPQDF---------------------------------PFYYLQQ------------------G 412

  Fly   687 FRPIGKGLGGAGKEFGESLGGNYPREQFTIVMLTYEREQVLMDSLGRLYGLPYLHKVVVVWNSPK 751
            .||.|:                     |:.::......|..:..:..:.|..:..:::|:|::.:
Human   413 SRPEGR---------------------FSALIWVGPPGQPPLKLIQAVAGSQHCAQILVLWSNER 456

  Fly   752 P-PLDDLRWPDIGVPVAVLRAPRNSLNNRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREH 815
            | |   .|||:..||:.|:...| .:::||.|:..|.|:|:||:|..:.|...|:.|.|.||:..
Human   457 PLP---SRWPETAVPLTVIDGHR-KVSDRFYPYSTIRTDAILSLDARSSLSTSEVDFAFLVWQSF 517

  Fly   816 RDRVVGFPGRYHAWDLGNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDE 880
            .:|:|||....|.||  ..:|.|.|.:..:.|.|||||.|||.|:||..|:|:.||:|:|...||
Human   518 PERMVGFLTSSHFWD--EAHGGWGYTAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKALRTLADE 580

  Fly   881 YMNCEDIAMNFLVSHITRKPPVKV-----TSRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVF 940
            ...|.|:.|||:|:.:|:.||:||     ........||.|....:......:   |||..:..|
Human   581 APTCVDVLMNFIVAAVTKLPPIKVPYGKQRQEAAPLAPGGPGPRPKPPAPAPD---CINQIAAAF 642

  Fly   941 GYTPLLNTQYRADSILFKTRIPHDKQK 967
            |:.|||:::.|.|.:|||..:...::|
Human   643 GHMPLLSSRLRLDPVLFKDPVSVQRKK 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168
		Exostosin	224..551	CDD:397245	67/343 (20%)
		Glyco_transf_64	714..953	CDD:430488	82/244 (34%)
EXTL1	NP_004446.2	Exostosin	92..335	CDD:397245	67/344 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..264		8/28 (29%)
		Glyco_transf_64	419..655	CDD:430488	82/244 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..631		3/20 (15%)