Protein Alignment botv and Ext2

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_034293.2
• Gene: Ext2 / 14043
• MGIID: 108050
• Length: 718
• Species: Mus musculus
• Alignment Length: 822
• Identity: 241/822 - (29%)
• Similarity: 375/822 - (45%)
• Gaps: 199/822 - (24%)

  Fly   180 RNTPDLALPRSLLPNTLPRKSNPITGGMAASCEMHNCFNHSRCSLT--SGFPVYLYDPDEHSVQR 242
            |..|.:.||..   :.:|.:.:       .||.||.||:..||...  :...||:| |.:..|..
Mouse    64 REVPVVRLPTD---SPIPERGD-------LSCRMHTCFDVYRCGFNPKNKIKVYIY-PLKKYVDD 117

  Fly   243 KGYDIDGFLK---TTLKQTLGYNAHIVKDPKHACIYLVLVGEALLEQDLLRNNRYAAQEAEHQQP 304
            .|..:...:.   ..|...:..:.:...|...||:::..:       |:|..|....:|.
Mouse   118 AGVPVSSAISREYNELLTAISDSDYYTDDINRACLFVPSI-------DVLNQNPLRIKET----- 170

  Fly   305 STPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNL---ARRDLTSHRTNPLYRQNTMRAIVVQSAF 366
                        .:.|..|..| ..|.||:|.|:   |..|..:....|     ..||::....|
Mouse   171 ------------AQALAQLSRW-DRGTNHLLFNMLPGAPPDYNTALDVP-----RDRALLAGGGF 217

  Fly   367 EREQFRPGYDLIVPPILGPPGGDVWQECAEMVPARRKY-LLTYQGELRPK-QSSLNPLDA----- 424
            ....:|.|||:.: |:..|...::  ...|..|..|:| ||:.|..:.|: :..|..|.|
Mouse   218 STWTYRQGYDVSI-PVFSPLSAEM--ALPEKAPGPRRYFLLSSQMAIHPEYREELEALQAKHQES 279

  Fly   425 -FILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDWTLCGSDSSRRQLLKDSTFSLILPPL 488
             .:|:...::::|...    ::.:|    .|.:....|            |:|:::||..:|.
Mouse   280 VLVLDKCTNLSEGVLS----VRKRC----HQHQVFDYP------------QVLQEATFCTVLR-- 322

  Fly   489 NGRVSSTLMLARIYEALRSGAVPVILGADELRLPYAETVDWRRTALLLPKARITELHFLLRAVQD 553
                .:.|..|.:.:.|::|.|||:: ||...||::|.:||:|.::::|:.::::::.:|:.:..
Mouse   323 ----GARLGQAVLSDVLQAGCVPVVI-ADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQNIPQ 382

  Fly   554 ADLLLLRRQGRLIWERYLSSVQATVDTVIASLRDRLGIPPRPVPSVIAQSVFNSTFIPLKSDPPV 618
            ..:..::||.|..||.|..|::|.....:..:.||:
Mouse   383 RQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRI----------------------------- 418

  Fly   619 GLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAKEAWND-----WL---DPFYLYPQLPFDPALP 675
                            ||..|.          :.|.|||     |.   :|.:|       |.:|
Mouse   419 ----------------YPYAAI----------SYEEWNDPPAVKWASVSNPLFL-------PLIP 450

  Fly   676 SEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQ-FTIVMLTYEREQVLMDSLGRLYGLPY 739
                                              |:.| ||.::|||:|.:.|...:..:..:|.
Mouse   451 ----------------------------------PQSQGFTAIVLTYDRVESLFRVITEVSKVPS 481

  Fly   740 LHKVVVVWNSP-KPPLDDLRWPDIGVPVAVLRAPRNSLNNRFLPFDVIETEAVLSVDDD-AHLRH 802
            |.|::||||:. |.|.::..||.|.||:.|:|...|.|:|||.|:|.|||||||::||| ..|..
Mouse   482 LSKLLVVWNNQNKNPPEESLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTS 546

  Fly   803 DEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNSNYSCELSMVLTGAAFVHKYYLYLYT 867
            ||:.||:.||||..||:||:|||.|.||  :...:|.|.|.::.|:|||||||||.|||:.||||
Mouse   547 DELQFGYEVWREFPDRLVGYPGRLHLWD--HEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYT 609

  Fly   868 YHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVTSRWTFRCPGCPV--SLSEDDTHFQERH 930
            |.:|..|::.||.:||||||||||||:::|.|..:|||.|..|:||.|..  .||.|.||..||.
Mouse   610 YKMPGDIKNWVDTHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERS 674

  Fly   931 KCINFFSRVFGYTPLLNTQYRADSILFKTRIPHDKQKCFKYI 972
            :|||.|:.|||..||...::|||.:|:|...| :|.|.|..|
Mouse   675 ECINKFASVFGTMPLKVVEHRADPVLYKDDFP-EKLKSFPNI 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168
		Exostosin	224..551	CDD:397245	72/342 (21%)
		Glyco_transf_64	714..953	CDD:430488	123/242 (51%)
Ext2	NP_034293.2	Exostosin	100..380	CDD:397245	72/340 (21%)
		Glyco_transf_64	456..697	CDD:430488	123/242 (51%)