Protein Alignment botv and Ext1

DIOPT Version :10

• Sequence 1: NP_523790.1
• Gene: botv / 37198
• FlyBaseID: FBgn0027535
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_034292.2
• Gene: Ext1 / 14042
• MGIID: 894663
• Length: 746
• Species: Mus musculus
• Alignment Length: 850
• Identity: 230/850 - (27%)
• Similarity: 369/850 - (43%)
• Gaps: 222/850 - (26%)

  Fly   175 REAVQRNTPDLALPRSLLPNTL-------------------PRKSNPITGGM--AASCEMHNCFN 218
            |..:.:.:||...||  .|:.|                   ||:.......:  ...|.|.:||:
Mouse    43 RNGLHQPSPDHFWPR--FPDALRPFFPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFD 105

  Fly   219 HSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHACIYLVLVGEAL 283
            .:.|. .:||.||:|.      |:||..|....:..|....| :.....||..||::       :
Mouse   106 FTLCK-KNGFKVYVYP------QQKGEKIAESYQNILAAIEG-SRFYTSDPSQACLF-------V 155

  Fly   284 LEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRT 348
            |..|.|..::.:.|...:.:              .|:.||..| .:||||::.||      ...|
Mouse   156 LSLDTLDRDQLSPQYVHNLR--------------SKVQSLHLW-NNGRNHLIFNL------YSGT 199

  Fly   349 NPLYRQNT----MRAIVVQSAFEREQFRPGYDLIVP------PILGPPGGDVWQECAEMVPARRK 403
            .|.|.::.    .:|::.:::...|.|||.:|:.:|      |..|...|.:   ....:|..||
Mouse   200 WPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFL---KFNTIPPLRK 261

  Fly   404 YLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDW----- 463
            |:|.::|     :..|..:.:.....|..:..|  :|..:|       |..:.|   .||
Mouse   262 YMLVFKG-----KRYLTGIGSDTRNALYHVHNG--EDVLLL-------TTCKHG---KDWQKHKD 309

  Fly   464 TLCGSDSSR------RQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLP 522
            :.|..|::.      |::|.::||.|:  |...|:.|    .|..|||::..|||:| ::...||
Mouse   310 SRCDRDNTEYEKYDYREMLHNATFCLV--PRGRRLGS----FRFLEALQAACVPVML-SNGWELP 367

  Fly   523 YAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVDTVIASLRD 587
            ::|.::|.:.|::..:..:.::...:|::....:|.||:|.:.:||.|.|||:..|.|.:..::|
Mouse   368 FSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQD 432

  Fly   588 RLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAK 652
            |           |.:.:..::.|..|.  |.||...|:
Mouse   433 R-----------IFKHISRNSLIWNKH--PGGLFVLPQ--------------------------- 457

  Fly   653 EAWNDWLDPF-YLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQFTI 716
              ::.:|..| |.|..|                 |.:|..|                     ||.
Mouse   458 --YSSYLGDFPYYYANL-----------------GLKPPSK---------------------FTA 482

  Fly   717 VMLT----YEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAVLRAPRNSLN 777
            |:..    ..:.|.::..|.......|..:::|:||..||.....|||...|||.|:......::
Mouse   483 VIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVIVIEGESKVMS 547

  Fly   778 NRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNS 842
            :||||:|.|.|:||||:|:|..|...|:.|.|.||:...:|:||:|.|.|.||  |...:|.|.|
Mouse   548 SRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD--NSKERWGYTS 610

  Fly   843 NYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVT-- 905
            .::.:.||||||||..||||.|||:::||.::::.||:..|||||.||||||.:|:.||:|||
Mouse   611 KWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQK 675

  Fly   906 --------------SRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSIL 956
                          |||.            |..||.:|..|:|.|:..|||.||:::|.|.|.:|
Mouse   676 KQYKETMMGQTSRASRWA------------DPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVL 728

  Fly   957 FKTRI 961
            ||.::
Mouse   729 FKDQV 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	CC_brat-like	106..>179	CDD:475168	1/3 (33%)
		Exostosin	224..551	CDD:397245	81/347 (23%)
		Glyco_transf_64	714..953	CDD:430488	102/258 (40%)
Ext1	NP_034292.2	Exostosin	110..396	CDD:397245	81/348 (23%)
		Glyco_transf_64	480..725	CDD:430488	102/258 (40%)