DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment botv and Ext1

DIOPT Version :9

Sequence 1:	NP_523790.1	Gene:	botv / 37198	FlyBaseID:	FBgn0027535	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_034292.2	Gene:	Ext1 / 14042	MGIID:	894663	Length:	746	Species:	Mus musculus

Alignment Length:	850	Identity:	230/850 - (27%)
Similarity:	369/850 - (43%)	Gaps:	222/850 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 REAVQRNTPDLALPRSLLPNTL-------------------PRKSNPITGGM--AASCEMHNCFN 218
            |..:.:.:||...||  .|:.|                   ||:.......:  ...|.|.:||:
Mouse    43 RNGLHQPSPDHFWPR--FPDALRPFFPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFD 105

  Fly   219 HSRCSLTSGFPVYLYDPDEHSVQRKGYDIDGFLKTTLKQTLGYNAHIVKDPKHACIYLVLVGEAL 283
            .:.|. .:||.||:|.      |:||..|....:..|....| :.....||..||::       :
Mouse   106 FTLCK-KNGFKVYVYP------QQKGEKIAESYQNILAAIEG-SRFYTSDPSQACLF-------V 155

  Fly   284 LEQDLLRNNRYAAQEAEHQQPSTPTLENDCPVDMEKLYSLPYWGGDGRNHVLLNLARRDLTSHRT 348
            |..|.|..::.:.|...:.:              .|:.||..| .:||||::.||      ...|
Mouse   156 LSLDTLDRDQLSPQYVHNLR--------------SKVQSLHLW-NNGRNHLIFNL------YSGT 199

  Fly   349 NPLYRQNT----MRAIVVQSAFEREQFRPGYDLIVP------PILGPPGGDVWQECAEMVPARRK 403
            .|.|.::.    .:|::.:::...|.|||.:|:.:|      |..|...|.:   ....:|..||
Mouse   200 WPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFL---KFNTIPPLRK 261

  Fly   404 YLLTYQGELRPKQSSLNPLDAFILEHLADMAKGATQDQFVLQFQCVPATEQQEGDSLPDW----- 463
            |:|.::|     :..|..:.:.....|..:..|  :|..:|       |..:.|   .||
Mouse   262 YMLVFKG-----KRYLTGIGSDTRNALYHVHNG--EDVLLL-------TTCKHG---KDWQKHKD 309

  Fly   464 TLCGSDSSR------RQLLKDSTFSLILPPLNGRVSSTLMLARIYEALRSGAVPVILGADELRLP 522
            :.|..|::.      |::|.::||.|:  |...|:.|    .|..|||::..|||:| ::...||
Mouse   310 SRCDRDNTEYEKYDYREMLHNATFCLV--PRGRRLGS----FRFLEALQAACVPVML-SNGWELP 367

  Fly   523 YAETVDWRRTALLLPKARITELHFLLRAVQDADLLLLRRQGRLIWERYLSSVQATVDTVIASLRD 587
            ::|.::|.:.|::..:..:.::...:|::....:|.||:|.:.:||.|.|||:..|.|.:..::|
Mouse   368 FSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQD 432

  Fly   588 RLGIPPRPVPSVIAQSVFNSTFIPLKSDPPVGLDTEPEESLGPIEPPYPSPAFRRNYTILRMQAK 652
            |           |.:.:..::.|..|.  |.||...|:
Mouse   433 R-----------IFKHISRNSLIWNKH--PGGLFVLPQ--------------------------- 457

  Fly   653 EAWNDWLDPF-YLYPQLPFDPALPSEAKFMGSHTGFRPIGKGLGGAGKEFGESLGGNYPREQFTI 716
              ::.:|..| |.|..|                 |.:|..|                     ||.
Mouse   458 --YSSYLGDFPYYYANL-----------------GLKPPSK---------------------FTA 482

  Fly   717 VMLT----YEREQVLMDSLGRLYGLPYLHKVVVVWNSPKPPLDDLRWPDIGVPVAVLRAPRNSLN 777
            |:..    ..:.|.::..|.......|..:::|:||..||.....|||...|||.|:......::
Mouse   483 VIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVIVIEGESKVMS 547

  Fly   778 NRFLPFDVIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRYHAWDLGNPNGQWHYNS 842
            :||||:|.|.|:||||:|:|..|...|:.|.|.||:...:|:||:|.|.|.||  |...:|.|.|
Mouse   548 SRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWD--NSKERWGYTS 610

  Fly   843 NYSCELSMVLTGAAFVHKYYLYLYTYHLPQAIRDKVDEYMNCEDIAMNFLVSHITRKPPVKVT-- 905
            .::.:.||||||||..||||.|||:::||.::::.||:..|||||.||||||.:|:.||:|||
Mouse   611 KWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQK 675

  Fly   906 --------------SRWTFRCPGCPVSLSEDDTHFQERHKCINFFSRVFGYTPLLNTQYRADSIL 956
                          |||.            |..||.:|..|:|.|:..|||.||:::|.|.|.:|
Mouse   676 KQYKETMMGQTSRASRWA------------DPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVL 728

  Fly   957 FKTRI 961
            ||.::
Mouse   729 FKDQV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
botv	NP_523790.1	TBPIP	<107..185	CDD:284512	2/9 (22%)
		Exostosin	224..551	CDD:281069	81/347 (23%)
		Glyco_transf_64	714..949	CDD:286358	100/254 (39%)
Ext1	NP_034292.2	Exostosin	110..396	CDD:397245	81/348 (23%)
		Glyco_transf_64	480..725	CDD:401264	102/258 (40%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	544..549		0/4 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	565..567		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	650..654		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	688..701		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920