DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15117 and manba

DIOPT Version :9

Sequence 1:	NP_725851.1	Gene:	CG15117 / 37197	FlyBaseID:	FBgn0034417	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_956453.1	Gene:	manba / 393128	ZFINID:	ZDB-GENE-040426-721	Length:	901	Species:	Danio rerio

Alignment Length:	735	Identity:	156/735 - (21%)
Similarity:	248/735 - (33%)	Gaps:	225/735 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SETREVR------SLDGIWNFVRSDQ--------------ANPTQGVRDEWYAKELSKSRPTIPM 98
            ||...:|      ||:|.|..|.|:.              |...|||..:.|.:
Zfish    25 SEASSLRLGDNIVSLNGKWQLVNSNSTFSLSAEVPGCVHTALQRQGVISDPYYR----------- 78

  Fly    99 PVPASYND-----ITTDNLRDHVGTVW-YDRKFFVPRSWSKDQ------RIWLRFGSVHYEAYVW 151
                 :||     |:.||        | |...|.:|....:.|      ::.|.|..|...:.:.
Zfish    79 -----FNDLAYRWISLDN--------WTYTTSFSLPACVEEVQDVQGKGKVVLVFEGVDTISTIS 130

  Fly   152 INGQKVVKHEMGHLPFEAEVTDLLSYGAENRITVMCDNALIQTTVPQGRITE--VPNDGGMTIVQ 214
            :||..:...:.....::.:||.||. ..||.:.|...:|:...:......|:  ||.|....:.:
Zfish   131 LNGVTIGTTDNMFRRYDFDVTGLLK-DQENILQVFIMSAVAYASQRSRAHTKYRVPPDCPPPVQK 194

  Fly   215 -------------SYTFDF---FNYAGIHRSVHL--YTTPRTFIEEVEVTTNLSKDATVG----- 256
                         |:::|:   |...||.:.|.|  :.|.|.    :..||:|..|:...
Zfish   195 GECHVNFIRKAQSSFSWDWGPSFPTLGIWKGVRLEVFNTFRV----LSFTTSLKYDSADSSWSVE 255

  Fly   257 -EVFYSVSVNGSAANEADNVLQIQANLYDKDGILVANATSDQ-KLGGKLQVNP---VKPWWPYLM 316
             |:|:.|.|      .:..::.|...|...:.....:.|..| |....||||.   |..|||: .
Zfish   256 VELFFDVVV------ASKGLVHISIPLLLSEAEFQLSLTPGQRKTSFILQVNQFQNVSLWWPF-G 313

  Fly   317 HSEPGYLYQLEIKLLATNDELLDVYRLKVGIRTLSWNSQ----------QFLINGKPVYFRG--- 368
            |.:. .||.|||.:...:.|.....|: |..||:....:          .|.|||||::.:|
Zfish   314 HGDQ-RLYNLEINVKLDDGETFKAQRM-VAFRTVELVQELIPSSPGLSFYFRINGKPIFLKGSNW 376

  Fly   369 -----FGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMIIDE- 427
                 |.....:|:....|.:| ...:.|.|:..|...|....:      ....|.:||||..:
Zfish   377 IPVHAFQDQVTTDMITVLLRSA-QKANMNALRVWGGGVYEQDFF------YNLCDMYGIMIWQDF 434

  Fly   428 ---CPSVDTE-NFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTGSVSAD---------- 478
               |....|| :|.|.:    :..:.|.:.|.::|||||:|| .|.....:::.|
Zfish   435 MFACALYPTERDFIQTV----REEITQQVRRLKSHPSVVIWS-GNNENEAAIATDWFNISVADRP 494

  Fly   479 ----SYFELVANFTRSL----DKTRPITAAIAVSNTQ-DKAGRSLDIISFNRYNAWYSNAGRLDM 534
                .|..|..:..|.:    |.|||...:...:..: ::.|    .::.|.|:   .|.|  |.
Zfish   495 LYVKDYVNLYVDNIRDIVLQEDSTRPFLVSSPTNGVESEREG----WVAQNPYD---PNFG--DT 550

  Fly   535 ITQNVIDEAIAWNKRYNKPIIMSEYG------ADTLEGLHMQPAYVWSEEF-------------- 579
            ...|...:...|. .:.:....||||      ..||..:.:...:.:|..|
Zfish   551 HYYNYFTDCWDWT-AFPRTRFASEYGFQSWPSLSTLSKVSVSSDWDFSSNFSAHRQHHEDGNQQM 614

  Fly   580 -------------------------------------QTEVFSRHFKAFDELRKKGWFIGEFVWN 607
                                                 |||.:.|......|  .||..:|...|.
Zfish   615 LRQAELHYILPNSTDSVQRYRDTIYITQVMQAQCVKIQTEFYRRSRSDISE--GKGHTMGTLYWQ 677

  Fly   608 FADFKTAQSYTRV--GGNKK 625
            ..|.....|::.|  ||..|
Zfish   678 LNDIWQGPSWSSVEFGGKWK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15117	NP_725851.1	PRK10150	48..648	CDD:236657	156/735 (21%)
		Glyco_hydro_2_N	57..236	CDD:280926	46/230 (20%)
		Glyco_hydro_2	238..348	CDD:279093	30/119 (25%)
		Glyco_hydro_1	356..645	CDD:304882	74/361 (20%)
manba	NP_956453.1	LacZ	38..858	CDD:225789	153/722 (21%)
		Glyco_hydro_2_N	<94..163	CDD:280926	15/69 (22%)
		Glyco_hydro_2	237..343	CDD:279093	30/114 (26%)
		Glyco_hydro_1	362..>508	CDD:304882	38/157 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810