Protein Alignment CG15117 and GUSB

DIOPT Version :9

• Sequence 1: NP_725851.1
• Gene: CG15117 / 37197
• FlyBaseID: FBgn0034417
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_000172.2
• Gene: GUSB / 2990
• HGNCID: 4696
• Length: 651
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 296/642 - (46%)
• Similarity: 410/642 - (63%)
• Gaps: 41/642 - (6%)

  Fly    47 GMLYPRESETREVRSLDGIWNFVRSDQANPTQGVRDEWYAKELSKSRPTIPMPVPASYNDITTD- 110
            |||||:||.:||.:.|||:|:|......|..:|..::||.:.|.:|.||:.||||:|:|||:.|
Human    26 GMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDW 90

  Fly   111 NLRDHVGTVWYDRKFFVPRSWSKD--QRIWLRFGSVHYEAYVWINGQKVVKHEMGHLPFEAEVTD 173
            .||..||.|||:|:..:|..|::|  .|:.||.||.|..|.||:||...::||.|:|||||::::
Human    91 RLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISN 155

  Fly   174 LLSYG---AENRITVMCDNALIQTTVPQGRI---TEVPNDGGMTIVQSYTFDFFNYAGIHRSVHL 232
            |:..|   :..|||:..:|.|..||:|.|.|   |:.........||:..||||||||:.|||.|
Human   156 LVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLL 220

  Fly   233 YTTPRTFIEEVEVTTNLSKDATVGEVFYSVSVNGSAANEADNVLQIQANLYDKDGILVANATSDQ 297
            ||||.|:|:::.|||::.:|:  |.|.|.:||.||      |:.:::..|.|.:..:|||.|..|
Human   221 YTTPTTYIDDITVTTSVEQDS--GLVNYQISVKGS------NLFKLEVRLLDAENKVVANGTGTQ 277

  Fly   298 KLGGKLQVNPVKPWWPYLMHSEPGYLYQLEIKLLATND--ELLDVYRLKVGIRTLSWNSQQFLIN 360
               |:|:|..|..|||||||..|.|||.||::|.|...  .:.|.|.|.|||||::....|||||
Human   278 ---GQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLIN 339

  Fly   361 GKPVYFRGFGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMII 425
            |||.||.|..:|||:||||||.|..|:|:|||||:|:||||:|||||||:||.||..|.:||::|
Human   340 GKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVI 404

  Fly   426 DECPSVD---TENFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTGSVSADSYFELVANF 487
            ||||.|.   .:.|:...|..|...:|:::.||:|||:|||||:||||.:...||..|.::|...
Human   405 DECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAH 469

  Fly   488 TRSLDKTRPITAAIAVSNTQ---DKAGRSLDIISFNRYNAWYSNAGRLDMITQNVIDEAIAWNKR 549
            |:|||.:||:|   .|||:.   ||....:|:|..|.|.:||.:.|.|::|...:..:...|.|:
Human   470 TKSLDPSRPVT---FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKK 531

  Fly   550 YNKPIIMSEYGADTLEGLHMQPAYVWSEEFQTEVFSRHFKAFDELRKKGWFIGEFVWNFADFKTA 614
            |.||||.|||||:|:.|.|..|..:::||:|..:..::....|:.|:| :.:||.:||||||.|.
Human   532 YQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRK-YVVGELIWNFADFMTE 595

  Fly   615 QSYTRVGGNKKGVFTRARQPKAAAHLLRKRYFALGRDL--------DQCSFPEDLFT 663
            ||.|||.|||||:|||.||||:||.|||:||:.:..:.        .|| ....|||
Human   596 QSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQC-LENSLFT 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15117	NP_725851.1	PRK10150	48..648	CDD:236657	290/616 (47%)
		Glyco_hydro_2_N	57..236	CDD:280926	83/187 (44%)
		Glyco_hydro_2	238..348	CDD:279093	45/111 (41%)
		Glyco_hydro_1	356..645	CDD:304882	149/294 (51%)
GUSB	NP_000172.2	Glyco_hydro_2	27..631	CDD:332472	290/618 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144919
Domainoid	1	1.000	313	1.000	Domainoid score	I1297
eggNOG	1	0.900	-	-		E1_COG3250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37271
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1077
Isobase	1	0.950	-	0	Normalized mean entropy	S3840
OMA	1	1.010	-	-		QHG61039
OrthoDB	1	1.010	-	-		D153017at33208
OrthoFinder	1	1.000	-	-		FOG0002553
OrthoInspector	1	1.000	-	-		otm40589
orthoMCL	1	0.900	-	-		OOG6_104811
Panther	1	1.100	-	-	LDO	PTHR10066
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4158
SonicParanoid	1	1.000	-	-		X3251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750