Protein Alignment 5-HT1A and TAAR2

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001028252.1
• Gene: TAAR2 / 9287
• HGNCID: 4514
• Length: 351
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 101/627 - (16%)
• Similarity: 153/627 - (24%)
• Gaps: 364/627 - (58%)

  Fly   224 LRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI 288
            :|:|:.|.:.| .|.:||.||:.:|.:|...:.|....|:|:.|:|:.|..:...:||...:..:
Human    42 VRVAMYSFMAG-SIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSV 105

  Fly   289 SQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTA 352
            ...|..|...|.|:.|.|::....||.||.::|:||::|:. .:.|....|...:..::...|:.
Human   106 ENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSV 170

  Fly   353 ------AVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCT----------------- 394
                  .|:.|.|         |...||          .|.:...|.:
Human   171 PGAFAFGVVFSEA---------YADGIE----------GYDILVACSSSCPVMFNKLWGTTLFMA 216

  Fly   395 -FYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAK 458
             |:.|..:::.:|.||:..:||..|         |:||                 ||
Human   217 GFFTPGSMMVGIYGKIFAVSRKHAH---------AINN-----------------LR-------- 247

  Fly   459 SKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVS 523
                                                                             
Human   248 ----------------------------------------------------------------- 247

  Fly   524 HLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAM 588
                                                           |:|:.||
Human   248 -----------------------------------------------ENQNNQV----------- 254

  Fly   589 TAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQT 653
                                                                             
Human   255 ----------------------------------------------------------------- 254

  Fly   654 PTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQ 718
                                                                             
Human   255 ----------------------------------------------------------------- 254

  Fly   719 QQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQIS 783
                                     |:::||||||.|:.|.|::||.|.|...|..|.   ...|
Human   255 -------------------------KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPF---LNFS 291

  Fly   784 DSVASLF---LWLGYFNSTLNPVIYTIFSPEFRQAFKRILFG 822
            ..|. ||   .|.||||||.||:||..|.|.||:|.|.||.|
Human   292 TPVV-LFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLG 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	48/210 (23%)
		TM helix 1	228..254	CDD:320454	9/25 (36%)
		TM helix 2	261..287	CDD:320454	7/25 (28%)
		TM helix 3	299..329	CDD:320454	12/29 (41%)
		TM helix 4	340..362	CDD:320454	4/27 (15%)
		TM helix 5	383..412	CDD:320454	7/46 (15%)
		7tm_GPCRs	<743..816	CDD:475119	35/75 (47%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	14/27 (52%)
TAAR2	NP_001028252.1	7tmA_TAAR2_3_4	44..326	CDD:320437	95/617 (15%)
		TM helix 1	45..71	CDD:320437	10/26 (38%)
		TM helix 2	78..104	CDD:320437	7/25 (28%)
		TM helix 3	116..146	CDD:320437	12/29 (41%)
		TM helix 4	158..181	CDD:320437	2/22 (9%)
		TM helix 5	206..235	CDD:320437	5/28 (18%)
		TM helix 6	255..285	CDD:320437	15/29 (52%)
		TM helix 7	294..319	CDD:320437	14/25 (56%)