Protein Alignment 5-HT1A and TAAR5

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 101/597 - (16%)
• Similarity: 148/597 - (24%)
• Gaps: 334/597 - (55%)

  Fly   237 ILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDI 301
            :|:.::|||||..|:...:.|....|:|:.|||:||:|:..||:||..:..:...|..|..||.:
Human    45 MLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRL 109

  Fly   302 WTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFM-MIFCVW-TAAVIVSLAPQFGW 364
            .|..|.|.|..||.||..|::||:.|:.:.....|:.:.||.: .|...| ..|...||......
Human   110 HTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDV 174

  Fly   365 KDPDYLQRIEQQKCMVSQDVSYQVF---ATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVD 426
            .:....|.:|:..|:.|..:....|   .....|:||.|::::||.||:..|.:
Human   175 VETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATR----------- 228

  Fly   427 AAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTV 491
                                                                             
Human   229 ----------------------------------------------------------------- 228

  Fly   492 EDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDG 556
                                                                             
Human   229 ----------------------------------------------------------------- 228

  Fly   557 QRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQ 621
                                                                       |.:|:.
Human   229 -----------------------------------------------------------QAQQIT 234

  Fly   622 QLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLC 686
            .|.||:     .||
Human   235 TLSKSL-----AGA--------------------------------------------------- 243

  Fly   687 GTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAK 751
                                                                    ||.||||||
Human   244 --------------------------------------------------------AKHERKAAK 252

  Fly   752 TLAIITGAFVVCWLPFFVMA--------LTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIF 808
            ||.|..|.:::|||||.:..        :|.||         |..:|:|..||||..||:||...
Human   253 TLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPL---------VFDIFIWFAYFNSACNPIIYVFS 308

  Fly   809 SPEFRQAFKRIL 820
            ...||:|.|..|
Human   309 YQWFRKALKLTL 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	57/180 (32%)
		TM helix 1	228..254	CDD:320454	7/16 (44%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	13/29 (45%)
		TM helix 4	340..362	CDD:320454	7/23 (30%)
		TM helix 5	383..412	CDD:320454	9/31 (29%)
		7tm_GPCRs	<743..816	CDD:475119	33/80 (41%)
		TM helix 6	750..772	CDD:410628	11/29 (38%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	98/591 (17%)
		TM helix 1	36..62	CDD:320441	7/16 (44%)
		TM helix 2	69..95	CDD:320441	12/25 (48%)
		TM helix 3	107..137	CDD:320441	13/29 (45%)
		TM helix 4	149..172	CDD:320441	7/22 (32%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		2/12 (17%)
		TM helix 5	196..225	CDD:320441	9/28 (32%)
		TM helix 6	245..275	CDD:320441	16/29 (55%)
		TM helix 7	284..309	CDD:320441	13/33 (39%)