DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and htr1ab

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001139238.1 Gene:htr1ab / 797538 ZFINID:ZDB-GENE-090409-2 Length:403 Species:Danio rerio


Alignment Length:648 Identity:183/648 - (28%)
Similarity:250/648 - (38%) Gaps:258/648 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 NDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTS-KVAEDDFTQLLRMAVTSVLLGLMIL 238
            |||..|..|||.|        ..|.|        |||.. ||      .|.....||:|:|.:||
Zfish     5 NDTSFLFQNDSDL--------DHQTD--------NVTLPVKV------PLSYQISTSLLIGALIL 47

  Fly   239 VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWT 303
            .:|.||..|:|||.|||:||||||||:.||||.||.|:.||:|:.|:|::...|.||...|||:.
Zfish    48 CSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLDKWTLGQVTCDIFI 112

  Fly   304 SCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDP 367
            |.|:||||:|||||.|||:|||||:|: |||:..||..|..::|...|.....:|:.|..     
Zfish   113 SLDILCCTSSILHLCAIALDRYWAITDPIDYMKKRTLKRAALLITVTWFVGFSISIPPML----- 172

  Fly   368 DYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNN 432
              :.:.:.:.||:|.|..|.:::|.|.||:||:::|.||.:|::.||.||.:...:|        
Zfish   173 --IMKSQPKTCMISHDPWYTIYSTFCAFYIPLILMLVLYGRIFKAARFRIRKTVRKP-------- 227

  Fly   433 QPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFS 497
                                     :.|....:.|| ||...||.|.:   |.|..:.||     
Zfish   228 -------------------------EKKRVKCLTVS-PALFKRANGEL---SKNWKSAVE----- 258

  Fly   498 SSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHG 562
                                                   .|.:|.|||..   :..:||:     
Zfish   259 ---------------------------------------PKPAACVNGAI---KHAEDGE----- 276

  Fly   563 EQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSV 627
                                                     .:|::|                 |
Zfish   277 -----------------------------------------SLEIIE-----------------V 283

  Fly   628 KSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANES 692
            .|.     |.:|.                                           ||       
Zfish   284 HSN-----SKNNL-------------------------------------------PL------- 293

  Fly   693 PSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIIT 757
                      |.||...|               ...|..:|..:.|..|...||||..|||.||.
Zfish   294 ----------PNTPNSVP---------------LFENKHEKNTEAKRKLALARERKTVKTLGIIM 333

  Fly   758 GAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            |.|::||||||:.||.||.|..|.:...:..:..||||.||.|||:||..|:.:|:.|||:|:
Zfish   334 GTFILCWLPFFIKALVMPFCPTCVMPLWLQDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKII 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 87/186 (47%)
TM helix 1 228..254 CDD:320454 13/25 (52%)
TM helix 2 261..287 CDD:320454 15/25 (60%)
TM helix 3 299..329 CDD:320454 22/29 (76%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 12/28 (43%)
7tm_GPCRs <743..816 CDD:355774 36/72 (50%)
TM helix 6 747..772 CDD:341315 15/24 (63%)
TM helix 7 784..809 CDD:341315 11/24 (46%)
htr1abNP_001139238.1 7tm_4 46..>208 CDD:304433 80/168 (48%)
7tm_1 52..381 CDD:278431 152/562 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 279 1.000 Domainoid score I1659
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 305 1.000 Inparanoid score I2621
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D310620at33208
OrthoFinder 1 1.000 - - FOG0002041
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104614
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X366
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.970

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