DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and parietopsin

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_017209595.1	Gene:	parietopsin / 796632	ZFINID:	ZDB-GENE-101129-2	Length:	641	Species:	Danio rerio

Alignment Length:	698	Identity:	149/698 - (21%)
Similarity:	262/698 - (37%)	Gaps:	137/698 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 NDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFV 247
            ::|:.|.|.:.|.:.|                    :..|.:.:||..::|.:.:.|.|:.|:||
Zfish     3 SNSTAFWEQVKNNTWQ--------------------ETAQAVFVAVNCLVLLVALHVGIVANLFV 47

  Fly   248 IAAIILERNLQNVANYLVASLAVADLFVACLVMP--LGAVYEISQGWILGPELCDIWTSCDVLCC 310
            ..|:..:::||...|.|:.:|||.|:|...:..|  |..:...|....||...|.:..:...|.|
Zfish    48 AWAVYRQKSLQTSNNALLVNLAVIDIFRCSIDCPLLLSIIVSSSDAHDLGLLFCSVQIASFSLIC 112

  Fly   311 TASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVS-LAPQFGWKDPDYLQ-RI 373
            ...:|.|..|:.:|:.|:.| .:..:....|:.:.|...|...:.:| :...|....|.|:: |.
Zfish   113 CVQLLTLACISAERFQAIAN-PFKSAERRKRIMVWIPLTWLVPISISAICVIFAKDSPVYVRCRG 176

  Fly   374 EQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIY------------------QTARKRIHRR 420
            .|.:.:.|.| ::..:.....::|.|.:|:..|.:|:                  ...:|...::
Zfish   177 LQMETLDSYD-TFGFYILIPVWFVCLTIIIGFYGRIFLLVKAHERKIFDKGSLPPPDKKKEDKKQ 240

  Fly   421 RPRPVDAAV--NNNQPD---GGAATDTKLHRLRLRLGRFSTAKSKTGSAV--------------- 465
            :.:.::|..  :|..|.   .|.|:...|..:...|.:.:.:.|...:..
Zfish   241 KKKEINAIFKSDNKNPQMEANGKASCGDLKPVSEELPKTTVSDSLNSNMAKKLDKDKLNNEEPLI 305

  Fly   466 --GVSGPASGGRALGLVDGNSTNT---------VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQI 519
              |:..|:         |..:|:|         |:.||.|.|..||.|....:..:.......::
Zfish   306 FKGIMEPS---------DHQNTSTESSPTFNEDVSVVEKTSFQISNEDISEESLGDVEPNDYQKV 361

  Fly   520 ATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTA 584
            |..| |.:..|.:......|.:.....||..|......|      ||.|  |..:||:.....|:
Zfish   362 APES-LQSSEKLKNHQDTTSPSNFESNAPEDRTSFPNVR------EDPE--ESAEEQLKSHQNTS 417

  Fly   585 TSAMTAAGTNE-----SEDQCKANGV-EVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTI 643
            .|.....||.|     ||...|...: |.||:.| ...:...:|.:|.      |...|:|...|
Zfish   418 PSTNNENGTFERNILTSETSPKLRTIKERLENHQ-DITVPSTEQKKKD------GTFETNNLQDI 475

  Fly   644 TSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQ 708
            ||.::.:    :..|.|...:.|...|.....|.|               .|.|..::.|
Zfish   476 TSETSRT----SHDGRGEEHSKAQQDTTSEMCLMS---------------ETGEDGAKAP----- 516

  Fly   709 QPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALT 773
             |.....||:|::::::.....|..:.:| |...||:|.|.||....|...|:|.|:|.....:.
Zfish   517 -PGASDPQQKQEEEEMAGAVCMMPSLAQR-ERGNAKKESKLAKRSGYIIFTFLVFWIPLITTVIL 579

  Fly   774 MPLCA-----ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAF 816
            ....:     ..::...:..|.:.|....|..||:||...:|:||..|
Zfish   580 NHFYSRNGHLIMEVFRELEFLTVSLVCLTSITNPIIYAAVNPQFRTEF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	48/207 (23%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	9/27 (33%)
		TM helix 3	299..329	CDD:320454	8/29 (28%)
		TM helix 4	340..362	CDD:320454	4/22 (18%)
		TM helix 5	383..412	CDD:320454	6/46 (13%)
		7tm_GPCRs	<743..816	CDD:355774	21/77 (27%)
		TM helix 6	747..772	CDD:341315	8/24 (33%)
		TM helix 7	784..809	CDD:341315	7/24 (29%)
parietopsin	XP_017209595.1	7tm_4	39..>205	CDD:304433	42/167 (25%)
parietopsin	XP_017209595.1	7tm_1	44..>221	CDD:278431	43/178 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910