DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and drd1a

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_021336831.1 Gene:drd1a / 792634 ZFINID:ZDB-GENE-130522-1 Length:363 Species:Danio rerio


Alignment Length:639 Identity:142/639 - (22%)
Similarity:203/639 - (31%) Gaps:318/639 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 LNVTT----SKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVAS 267
            |||||    ..:..|..|::|    |...|.|:||.|::||..|.||:...|:|:: |.|:.|.|
Zfish     6 LNVTTVIDSGFMESDQSTRVL----TGCFLSLLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVIS 66

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-I 331
            |||:||.||.||||..||.|::..|..| ..||||.:.|::|.|||||:|..|:||||||::: .
Zfish    67 LAVSDLLVAILVMPWKAVTEVAGFWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPF 130

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGW--KDPDYL-------QRIEQQKCMVSQDVSY 386
            .|....|....|:||...||.:|::|..| |..|  ..|...       :.:....|..|.:.:|
Zfish   131 RYERKMTPRVAFVMISVAWTLSVLISFIPVQLKWHKAQPTSFPEANASHRALLTDNCDSSLNRTY 195

  Fly   387 QVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRL 451
            .:.::..:||:|:.:::..|.:||:.|:|:|.|     :.|...       ||...|:.      
Zfish   196 AISSSLISFYIPVAIMIVTYTQIYRIAQKQIRR-----ISALER-------AAESAKIR------ 242

  Fly   452 GRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSG 516
                                                    .|:..|||||||:|           
Zfish   243 ----------------------------------------HDSMGSSSNVDSES----------- 256

  Fly   517 NQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQP 581
                                                                             
Zfish   257 ----------------------------------------------------------------- 256

  Fly   582 TTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSI 646
                                                        |.|                  
Zfish   257 --------------------------------------------SFK------------------ 259

  Fly   647 SALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPH 711
                                                                             
Zfish   260 ----------------------------------------------------------------- 259

  Fly   712 QQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPL 776
                                         |..|||.|..|||::|.|.||.||||||::...:|.
Zfish   260 -----------------------------LSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPF 295

  Fly   777 CAACQ-----ISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHR 825
            |....     ||.:...:|:|.|:.||:|||:||. |:.:||:|| .||.|..|
Zfish   296 CKRTSVGLPCISPTTFDVFVWFGWANSSLNPIIYA-FNADFRRAF-AILLGCQR 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 74/197 (38%)
TM helix 1 228..254 CDD:320454 11/25 (44%)
TM helix 2 261..287 CDD:320454 16/25 (64%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 8/22 (36%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 34/77 (44%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 10/24 (42%)
drd1aXP_021336831.1 7tm_GPCRs 24..339 CDD:475119 129/610 (21%)
TM helix 1 27..51 CDD:410628 11/23 (48%)
TM helix 2 61..83 CDD:410628 14/21 (67%)
TM helix 3 98..120 CDD:410628 12/21 (57%)
TM helix 4 143..159 CDD:410628 6/15 (40%)
TM helix 5 193..216 CDD:410628 4/22 (18%)
TM helix 6 269..291 CDD:410628 13/21 (62%)
TM helix 7 308..333 CDD:410628 11/25 (44%)

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