Protein Alignment 5-HT1A and adrb3b

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_073770286.1
• Gene: adrb3b / 792519
• ZFINID: ZDB-GENE-081022-154
• Length: 415
• Species: Danio rerio
• Alignment Length: 629
• Identity: 128/629 - (20%)
• Similarity: 187/629 - (29%)
• Gaps: 305/629 - (48%)

  Fly   208 LNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVAD 272
            ::..|:.:..:|...||.:.     |.|:|.:|:|||:.||.||.....|....|..:.|:|.||
Zfish     1 MSANTTTLIPEDVKPLLVLP-----LALVIFLTVIGNLLVILAIARTPLLHTTTNVFIISMAFAD 60

  Fly   273 LFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHS 336
            |.:.|:|.|||....::..|:||..:||:|||.||.|.||||..|.||||:||.|:|. :::...
Zfish    61 LIMGCVVQPLGLSMVVAGKWVLGNPMCDLWTSLDVFCVTASIETLCAIAVERYIAITRPLEHQVL 125

  Fly   337 RTSNRVFMMIFCVWTAAVIVSLAPQFGWKD-PDYLQRIE----QQKCMVSQDVSYQVFATCCTFY 396
            ....|...::..||..:.:||..|...... .:||...:    .:.|....:..|.:|::..:||
Zfish   126 LGKRRAAYIVCTVWIVSSLVSFVPIMNHNSRANYLAANDCYNNSECCDFHTNQHYAIFSSVVSFY 190

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKT 461
            |||||::.||.|::..|.|::
Zfish   191 VPLLVMVFLYGKVFAIANKQL-------------------------------------------- 211

  Fly   462 GSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLV 526
                                                                             
Zfish   212 ----------------------------------------------------------------- 211

  Fly   527 ALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAA 591
               |..||                               ||...
Zfish   212 ---KLIGK-------------------------------DRLRF--------------------- 221

  Fly   592 GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS 656
                                                                             
Zfish   222 ----------------------------------------------------------------- 221

  Fly   657 QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQ 721
                               |:|||:         :|...||..:|.
Zfish   222 -------------------LSSCNE---------DSCEIPEGSARS------------------- 239

  Fly   722 QQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSV 786
                         ..|:.|....:|.||.|||.||.|.|.:||||||:..:......  ::...:
Zfish   240 -------------YSRRTTKHVVKEHKALKTLGIIMGIFSLCWLPFFIFNIIKSFNP--EVPTQL 289

  Fly   787 ASLFL-WLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHY 829
            ..|.| ||||.||.|||:|| ..|||:|.||..:| |..:|.|:
Zfish   290 VFLLLNWLGYANSGLNPIIY-CHSPEYRNAFFNLL-GCKKPKHF 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	68/191 (36%)
		TM helix 1	228..254	CDD:320454	11/25 (44%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	20/29 (69%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:475119	33/73 (45%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	13/25 (52%)
adrb3b	XP_073770286.1	None