Protein Alignment 5-HT1A and Htr5b

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_077371.1
• Gene: Htr5b / 79247
• RGDID: 62388
• Length: 370
• Species: Rattus norvegicus
• Alignment Length: 641
• Identity: 155/641 - (24%)
• Similarity: 215/641 - (33%)
• Gaps: 302/641 - (47%)

  Fly   183 NDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFV 247
            :||...|..:.:..|.| :::|           .|..|:....:.||  ||.|:|..|.:.|:.|
  Rat    23 SDSPSSGRSMGSTPGGL-ILSG-----------REPPFSAFTVLVVT--LLVLLIAATFLWNLLV 73

  Fly   248 IAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG--WILGPELCDIWTSCDVLCC 310
            :..|:..|....|.:.||||.||:|:.||.|||||..|.|:|.|  |.||..||.:|.|.|||||
  Rat    74 LVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCC 138

  Fly   311 TASILHLVAIAVDRYWAVTNIDYIHSRTSNRV-FMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRI 373
            ||||.::.|||:||||.:|.......||..|. .:||...|..:.:::||| .|||.:. |..|:
  Rat   139 TASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEA-YDARL 202

  Fly   374 EQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGA 438
              |:|.|||:.||.||:||..|||||.|:|.:|||||:.|:.|..|||
  Rat   203 --QRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRR----------------- 248

  Fly   439 ATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDS 503
                                                                             
  Rat   249 ----------------------------------------------------------------- 248

  Fly   504 KSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDRE 568
              ||.|..|:|:                |.|...:.|..|
  Rat   249 --RAVVPLPATT----------------QAKEAPQESETV------------------------- 270

  Fly   569 ELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGG 633
                               .||        :|:|.
  Rat   271 -------------------FTA--------RCRAT------------------------------ 278

  Fly   634 GASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698
                                       :|...:|
  Rat   279 ---------------------------VAFQTSG------------------------------- 285

  Fly   699 RSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVC 763
                                                    ::...::|::||..:.|:.|.||:|
  Rat   286 ----------------------------------------DSWREQKEKRAAMMVGILIGVFVLC 310

  Fly   764 WLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRI 819
            |:|||:..|..||| ||.:.....|:||||||.||..||:|||.|:..:..|||.:
  Rat   311 WIPFFLTELVSPLC-ACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSL 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	91/189 (48%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	19/29 (66%)
		TM helix 4	340..362	CDD:320454	7/23 (30%)
		TM helix 5	383..412	CDD:320454	18/28 (64%)
		7tm_GPCRs	<743..816	CDD:355774	33/72 (46%)
		TM helix 6	747..772	CDD:341315	11/24 (46%)
		TM helix 7	784..809	CDD:341315	14/24 (58%)
Htr5b	NP_077371.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		3/12 (25%)
		7tm_1	69..351	CDD:278431	133/565 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010