DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and htr2b

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001038208.1 Gene:htr2b / 751784 ZFINID:ZDB-GENE-081022-57 Length:443 Species:Danio rerio


Alignment Length:618 Identity:135/618 - (21%)
Similarity:204/618 - (33%) Gaps:277/618 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI-SQGWI 293
            ::|:.|:|:.||.||:.||.|:.|||.|||..|:.:.|||||||.|..||||:..|..: :..|.
Zfish    18 ALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNSTWP 82

  Fly   294 LGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVS 357
            |...||.||...|||..||||:||.||::|||.|:.. |.:...::..:|...|..||..::.::
Zfish    83 LADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISIGIA 147

  Fly   358 L-APQFGWK--DPDYLQRIEQQKCMVSQD--VSYQVFATCCTFYVPLLVILALYWKIYQTARKRI 417
            : .|..|.:  |...:...:...|::|.:  ..::|:.:...|::||.:::.:|....|..||  
Zfish   148 IPIPIKGLQFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQVLRK-- 210

  Fly   418 HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDG 482
                                     |.:.||.|..|                             
Zfish   211 -------------------------KAYLLRSRAAR----------------------------- 221

  Fly   483 NSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMA 547
                                         ||     |:||                         
Zfish   222 -----------------------------PS-----ISTV------------------------- 227

  Fly   548 PSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQ 612
                                                                             
Zfish   228 ----------------------------------------------------------------- 227

  Fly   613 LQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLT 677
            .||:|..:...:|.|.|.|           |.....|:|..|.                      
Zfish   228 FQQELSVLASPEKMVISNG-----------IKRDRTLNPVNPI---------------------- 259

  Fly   678 SCNQSHPLCGTANESP----STPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRK 738
                      |.:|.|    ||...||.|..|                                 
Zfish   260 ----------TGDEVPLRRMSTIGKRSMQNLT--------------------------------- 281

  Fly   739 ETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAAC--QISDSVASLFLWLGYFNSTLN 801
                  .|::|:|.|.|:...|||.|.|||:..:|..||..|  .:.|.:..:|.|:||.:|.:|
Zfish   282 ------NEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVGYVSSGIN 340

  Fly   802 PVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL 834
            |::||:|:..||.||:|.:...::.|  |:.||
Zfish   341 PLVYTLFNRTFRLAFRRYITCNYKSV--RTPKL 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 67/189 (35%)
TM helix 1 228..254 CDD:320454 10/23 (43%)
TM helix 2 261..287 CDD:320454 14/25 (56%)
TM helix 3 299..329 CDD:320454 18/29 (62%)
TM helix 4 340..362 CDD:320454 5/22 (23%)
TM helix 5 383..412 CDD:320454 5/30 (17%)
7tm_GPCRs <743..816 CDD:475119 29/74 (39%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 10/24 (42%)
htr2bNP_001038208.1 7tm_GPCRs 15..362 CDD:475119 131/605 (22%)
TM helix 1 17..41 CDD:410628 10/22 (45%)
TM helix 2 50..72 CDD:410628 13/21 (62%)
TM helix 3 89..111 CDD:410628 13/21 (62%)
TM helix 4 134..150 CDD:410628 3/15 (20%)
TM helix 5 179..202 CDD:410628 4/22 (18%)
TM helix 6 287..309 CDD:410628 10/21 (48%)
TM helix 7 323..348 CDD:410628 10/24 (42%)

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